Enhancing membrane modulus of giant unilamellar lipid vesicles by lateral co-assembly of amphiphilic triblock copolymers
- Title
- Enhancing membrane modulus of giant unilamellar lipid vesicles by lateral co-assembly of amphiphilic triblock copolymers
- Author
- 이영복
- Keywords
- Giant unilamellar vesicles; Block copolymers; Lateral co-assembly; Membrane modulu
- Issue Date
- 2020-03
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Citation
- JOURNAL OF COLLOID AND INTERFACE SCIENCE, v. 561, page. 318-326
- Abstract
- We report a facile, but robust approach to fabricate structurally stable giant unilamellar vesicles (GUVs), on which a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayer membrane was made rigid by introducing amphiphilic block polymers. Particularly, we found that lateral co-assembly of an amphiphilic triblock copolymer (ATC) structured with a hydrophobic middle block and long molecular weight (20 K g/mol) hydrophilic end blocks remarkably enhanced the stretching modulus (k) of GUVs. When the membrane composition was optimized, the k value of ATC-hybridized GUVs increased to 6.2 x 10(8) Pa, which was approximately 10-fold higher than that of DPPC GUVs, thus leading to a much longer half-life. Moreover, we demonstrated that our ATC-hybridized GUVs enabled development of a fascinating vesicular model, which shows great potential as a structurally stable cell membrane mimic. (C) 2019 Elsevier Inc. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S0021979719312962https://repository.hanyang.ac.kr/handle/20.500.11754/163097
- ISSN
- 0021-9797
- DOI
- 10.1016/j.jcis.2019.10.109
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > CHEMICAL AND MOLECULAR ENGINEERING(화학분자공학과) > Articles
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