Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영복 | - |
dc.date.accessioned | 2021-07-22T05:31:18Z | - |
dc.date.available | 2021-07-22T05:31:18Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | JOURNAL OF COLLOID AND INTERFACE SCIENCE, v. 561, page. 318-326 | en_US |
dc.identifier.issn | 0021-9797 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0021979719312962 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/163097 | - |
dc.description.abstract | We report a facile, but robust approach to fabricate structurally stable giant unilamellar vesicles (GUVs), on which a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayer membrane was made rigid by introducing amphiphilic block polymers. Particularly, we found that lateral co-assembly of an amphiphilic triblock copolymer (ATC) structured with a hydrophobic middle block and long molecular weight (20 K g/mol) hydrophilic end blocks remarkably enhanced the stretching modulus (k) of GUVs. When the membrane composition was optimized, the k value of ATC-hybridized GUVs increased to 6.2 x 10(8) Pa, which was approximately 10-fold higher than that of DPPC GUVs, thus leading to a much longer half-life. Moreover, we demonstrated that our ATC-hybridized GUVs enabled development of a fascinating vesicular model, which shows great potential as a structurally stable cell membrane mimic. (C) 2019 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF)funded by the Ministry of Science, ICT & Future Planning (NRF-2018M3A9G2057170), and by the Bio-technology Development Program of MOTIE/KEIT (20000462). J.Y.K and I.C equally con-tributed to this work. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | en_US |
dc.subject | Giant unilamellar vesicles | en_US |
dc.subject | Block copolymers | en_US |
dc.subject | Lateral co-assembly | en_US |
dc.subject | Membrane modulu | en_US |
dc.title | Enhancing membrane modulus of giant unilamellar lipid vesicles by lateral co-assembly of amphiphilic triblock copolymers | en_US |
dc.type | Article | en_US |
dc.relation.volume | 561 | - |
dc.identifier.doi | 10.1016/j.jcis.2019.10.109 | - |
dc.relation.page | 318-326 | - |
dc.relation.journal | JOURNAL OF COLLOID AND INTERFACE SCIENCE | - |
dc.contributor.googleauthor | Kang, Jeong Yi | - |
dc.contributor.googleauthor | Choi, Ikjang | - |
dc.contributor.googleauthor | Seo, Mintae | - |
dc.contributor.googleauthor | Lee, Jin Yong | - |
dc.contributor.googleauthor | Hong, Sungjun | - |
dc.contributor.googleauthor | Gong, Gyeonghyeon | - |
dc.contributor.googleauthor | Shin, Song Seok | - |
dc.contributor.googleauthor | Lee, Youngbok | - |
dc.contributor.googleauthor | Kim, Jin Woong | - |
dc.relation.code | 2020052770 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING | - |
dc.identifier.pid | yblee | - |
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