ADVANCED SYNTHESIS & CATALYSIS, v. 362, no. 9, page. 1841-1845
Abstract
We have developed a catalytic asymmetric dearomative cyclization of homotryptamine derivatives, furnishing enantioenriched indolo[2,3-b]quinoline scaffolds. The activation of allenamides in the presence of chiral phosphoric acids triggered the dearomative cyclization in up to 99% ee.