Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls
- Title
- Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls
- Author
- 양승
- Keywords
- Precocious puberty; MKRN3; biomarker
- Issue Date
- 2019-08
- Publisher
- TAYLOR & FRANCIS LTD
- Citation
- GYNECOLOGICAL ENDOCRINOLOGY, v. 35, no. 8, page. 732-736
- Abstract
- This study evaluated the serum level of MKRN3 and investigated its diagnostic usefulness in girls with central precocious puberty (CPP). In total, 41 girls with CPP and 35 age-matched normal control girls were enrolled. Serum values of MKRN3 were measured in both groups. Gonadotropin and estradiol concentrations were evaluated after 6 and 12months of GnRH agonist (GnRHa) treatment in CPP patients. The MKRN3 concentrations were much lower in the patient group than in the control group (p=.005). Over 1 year of GnRHa treatment in patients, the gonadotropin concentrations were significantly decreased (p<.05), while the MKRN3 concentrations were unchanged (p>.05). MKRN3 levels were inversely correlated to standard deviation (SD) in height (r=-0.46, p=.000), SD in weight (r=-0.32, p=.005), Tanner stage (r=-0.41, p=.000), and bone age (r=-0.46, p=.000). Based on ROC analysis, the area under curve was 0.758 for MKRN3, with 82.9% sensitivity and 68.5% specificity. The measurement of serum MKRN3 level may provide some help for CPP prediction, but relatively various values need further validation.
- URI
- https://www.tandfonline.com/doi/full/10.1080/09513590.2019.1576615https://repository.hanyang.ac.kr/handle/20.500.11754/160754
- ISSN
- 0951-3590; 1473-0766
- DOI
- 10.1080/09513590.2019.1576615
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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