Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양승 | - |
dc.date.accessioned | 2021-03-22T05:21:29Z | - |
dc.date.available | 2021-03-22T05:21:29Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | GYNECOLOGICAL ENDOCRINOLOGY, v. 35, no. 8, page. 732-736 | en_US |
dc.identifier.issn | 0951-3590 | - |
dc.identifier.issn | 1473-0766 | - |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/09513590.2019.1576615 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/160754 | - |
dc.description.abstract | This study evaluated the serum level of MKRN3 and investigated its diagnostic usefulness in girls with central precocious puberty (CPP). In total, 41 girls with CPP and 35 age-matched normal control girls were enrolled. Serum values of MKRN3 were measured in both groups. Gonadotropin and estradiol concentrations were evaluated after 6 and 12months of GnRH agonist (GnRHa) treatment in CPP patients. The MKRN3 concentrations were much lower in the patient group than in the control group (p=.005). Over 1 year of GnRHa treatment in patients, the gonadotropin concentrations were significantly decreased (p<.05), while the MKRN3 concentrations were unchanged (p>.05). MKRN3 levels were inversely correlated to standard deviation (SD) in height (r=-0.46, p=.000), SD in weight (r=-0.32, p=.005), Tanner stage (r=-0.41, p=.000), and bone age (r=-0.46, p=.000). Based on ROC analysis, the area under curve was 0.758 for MKRN3, with 82.9% sensitivity and 68.5% specificity. The measurement of serum MKRN3 level may provide some help for CPP prediction, but relatively various values need further validation. | en_US |
dc.description.sponsorship | This study was supported by the Hallym University Research Fund 2014 (HURF-2014-23). | en_US |
dc.language.iso | en | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.subject | Precocious puberty | en_US |
dc.subject | MKRN3 | en_US |
dc.subject | biomarker | en_US |
dc.title | Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1080/09513590.2019.1576615 | - |
dc.relation.journal | GYNECOLOGICAL ENDOCRINOLOGY | - |
dc.contributor.googleauthor | Jeong, Hwal Rim | - |
dc.contributor.googleauthor | Lee, Hye Jin | - |
dc.contributor.googleauthor | Shim, Yeong Suk | - |
dc.contributor.googleauthor | Kang, Min Jae | - |
dc.contributor.googleauthor | Yang, Seung | - |
dc.contributor.googleauthor | Hwang, Il Tae | - |
dc.relation.code | 2019037822 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jxisfriend | - |
dc.identifier.orcid | http://orcid.org/0000-0002-3380-6962 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.