Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls

Abstract

This study evaluated the serum level of MKRN3 and investigated its diagnostic usefulness in girls with central precocious puberty (CPP). In total, 41 girls with CPP and 35 age-matched normal control girls were enrolled. Serum values of MKRN3 were measured in both groups. Gonadotropin and estradiol concentrations were evaluated after 6 and 12months of GnRH agonist (GnRHa) treatment in CPP patients. The MKRN3 concentrations were much lower in the patient group than in the control group (p=.005). Over 1 year of GnRHa treatment in patients, the gonadotropin concentrations were significantly decreased (p<.05), while the MKRN3 concentrations were unchanged (p>.05). MKRN3 levels were inversely correlated to standard deviation (SD) in height (r=-0.46, p=.000), SD in weight (r=-0.32, p=.005), Tanner stage (r=-0.41, p=.000), and bone age (r=-0.46, p=.000). Based on ROC analysis, the area under curve was 0.758 for MKRN3, with 82.9% sensitivity and 68.5% specificity. The measurement of serum MKRN3 level may provide some help for CPP prediction, but relatively various values need further validation.