Differential inhibition of prion propagation by enantiorners of quinacrine
- Title
- Differential inhibition of prion propagation by enantiorners of quinacrine
- Author
- 류종석
- Issue Date
- 2003-06
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- LABORATORY INVESTIGATION, v. 83, no. 6, page. 837-843
- Abstract
- Prion diseases are fatal neurologic disorders caused by accumulation of a pathogenic isoform (PrPSc) of the prion protein (PrP). The recent discovery of the inhibitory action of quinacrine on PrPSc formation in scrapie-infected neuroblastoma (ScN2a) cells raised the possibility of a treatment for patients with prion disease. To investigate the efficacy of quinacrine enantiomers, we measured the inhibitory effect of these isomers on PrPSc formation in ScN2a cells. (S)-quinacrine exhibited superior antiprion activity compared with (R)-quinacrine and two generic quinacrines that appear to be racemates. Treatment with these various forms of quinacrine did not induce adverse changes affecting cell survival and the expression of marker proteins over a range of potentially therapeutic concentrations. Thus, quinacrine enantiomers demonstrated stereoselectivity on prion elimination but not cytotoxicity in ScN2a cells. Our results raise the possibility that in vivo treatment using one enantiomer of quinacrine may be superior to a racemic mixture, which is the form that is generally used when quinacrine is employed to treat parasitic diseases.
- URI
- https://www.nature.com/articles/3780670https://repository.hanyang.ac.kr/handle/20.500.11754/156007
- ISSN
- 0023-6837
- DOI
- 10.1097/01.LAB.0000074919.08232.A2
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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