Preparation and evaluation of a porous molecularly imprinted polymer for selective recognition of the antiepileptic drug carbamazepine
- Title
- Preparation and evaluation of a porous molecularly imprinted polymer for selective recognition of the antiepileptic drug carbamazepine
- Author
- 김기현
- Keywords
- Porous molecularly imprinted polymer; Carbamazepine; Solid-phase extraction; Aqueous samples
- Issue Date
- 2019-09
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Citation
- Environmental Research, v. 176, article no. 108580
- Abstract
- A novel and porous molecularly imprinted polymer (PMIP) was synthesized and used as a solid-phase extraction adsorbent for preconcentration of carbamazepine (CBZ) prior to its quantitation by high-performance liquid chromatography (HPLC) in various sample forms (e.g., drinking water, river water, hospital wastewater, and pharmaceuticals). PMIP-CBZ was applied to a polymerization process in which polystyrene spheres were coated with a silica layer. Removal of polystyrene spheres and formation of porous silica facilitated the recovery of CBZ (99.4%) during the extraction process. Site accessibility to the surface of PMIP-CBZ increased the density of high-recognition sites. PMIP-CBZ was characterized by Fourier-transform infrared spectroscopy and scanning electron microscopy. The key variables influencing the extraction efficiency of PMIP (e.g., adsorbent loading, eluent type, eluent volume, reusability of the adsorbent, and cross-reactivity) were optimized. The optimized protocol was successfully employed to quantify CBZ with limit of detection and limit of quantification as 0.082 and 0.270 ng/mL, respectively (linear detection range: 0.5-250 ng/mL and a relative standard deviation: ˂ 5%). Use of the PMIP adsorbent resulted in a sensitive and stable method for efficiently quantitation of CBZ from various real sample matrices.
- URI
- https://www.sciencedirect.com/science/article/pii/S0013935119303779?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/153856
- ISSN
- 0013-9351; 1096-0953
- DOI
- 10.1016/j.envres.2019.108580
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > CIVIL AND ENVIRONMENTAL ENGINEERING(건설환경공학과) > Articles
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