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Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition
- Title
- Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition
- Author
- 류성언
- Keywords
- Dual specificity phosphatase; Mitogen-activated protein kinase; Enzyme inhibition; Structure activity relationship; Cancer
- Issue Date
- 2019-07
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v. 29, NO 14, Page. 1746-1748
- Abstract
- Structure based virtual screening attempts to discover DUSP1 inhibitors have yielded a scaffold featuring benzoxazole and acylthiourea pharmacophore. A series of its analogues were synthesized to explore structure activity relationship (SAR) of DUSP1 inhibition.
- URI
- https://www.sciencedirect.com/science/article/pii/S0960894X1930318X?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/151154
- ISSN
- 0960-894X; 1464-3405
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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