Stereoselective Palladium-Catalyzed α-Arylation of 3-Aryl-1-Indanones : Total Synthesis of (+)-Pauciflorol F
- Title
- Stereoselective Palladium-Catalyzed α-Arylation of 3-Aryl-1-Indanones : Total Synthesis of (+)-Pauciflorol F
- Author
- 이봉향
- Advisor(s)
- 허정녕, 신승훈
- Issue Date
- 2011-08
- Publisher
- 한양대학교
- Degree
- Master
- Abstract
- We have developed conditions for promoting highly efficient Pd-catalyzed α-arylation reactions of 3-aryl-1-indanones. Reactions employing the optimal catalytic system, involving Pd(OAc)2, X-Phos, and NaOtBu (1.1 equiv), are attended by decreased levels of formation of undesired products and they take place with high degrees of stereoselectivity. Additionally, this study has led to the first asymmetric synthesis of (+)-pauciflorol F in 5 steps, starting from the known acetophenone 33, in an overall 51% yield.
- URI
- https://repository.hanyang.ac.kr/handle/20.500.11754/138505http://hanyang.dcollection.net/common/orgView/200000417324
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > CHEMISTRY(화학과) > Theses (Master)
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