Synthetic Study on 4-Quinazolinone Derivatives and It's Application to Synthesis of N-Hetero Polycyclic Compounds via Intramolecular Cyclization

Abstract

Quinazolinone derivatives are interesting compound because of their broad-ranging biological activities. In addition, N-hetero polycyclic compounds based quinazolinone structure are founded many natural products and unnatural products in various biological activities and colored compounds. So We have developed two efficient synthesis methods for a variety quinazolinone derivatives (6, 8) through intermediate 4. Also, these two class of quinazolinone derivatives (6, 8) are expected to utilized for synthesis of quinazolinone based N-hetero polycyclic compounds via intramolecular cyclization.