Hierarchical Structural Component Analysis of microRNA-mRNA Integration Analysis
- Title
- Hierarchical Structural Component Analysis of microRNA-mRNA Integration Analysis
- Author
- 최성경
- Keywords
- miRNA; mRNA; Integration analysis; Generalized Structured Component Analysis (GSCA); Hierarchical structured component analysis of miRNA-mRNA integration (HisCoM-mimi)
- Issue Date
- 2018-05
- Publisher
- BIOMED CENTRAL LTD
- Citation
- BMC BIOINFORMATICS, v. 19, Article no. 75
- Abstract
- Background: Identification of multi-markers is one of the most challenging issues in personalized medicine era. Nowadays, many different types of omics data are generated from the same subject. Although many methods endeavor to identify candidate markers, for each type of omics data, few or none can facilitate such identification.
Results: It is well known that microRNAs affect phenotypes only indirectly, through regulating mRNA expression and/or protein translation. Toward addressing this issue, we suggest a hierarchical structured component analysis of microRNA-mRNA integration ("HisCoM-mimi") model that accounts for this biological relationship, to efficiently study and identify such integrated markers. In simulation studies, HisCoM-mimi showed the better performance than the other three methods. Also, in real data analysis, HisCoM-mimi successfully identified more gives more informative miRNA-mRNA integration sets relationships for pancreatic ductal adenocarcinoma (PDAC) diagnosis, compared to the other methods.
Conclusion: As exemplified by an application to pancreatic cancer data, our proposed model effectively identified integrated miRNA/target mRNA pairs as markers for early diagnosis, providing a much broader biological interpretation.
- URI
- https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-018-2070-0https://repository.hanyang.ac.kr/handle/20.500.11754/121384
- ISSN
- 1471-2105
- DOI
- 10.1186/s12859-018-2070-0
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > APPLIED MATHEMATICS(응용수학과) > Articles
- Files in This Item:
- 2018.05_최성경_Hierarchical structural component modeling of microRNA-mRNA integration analysis.pdfDownload
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