Poly-γ-glutamic acid suppresses osteoclastogenesis in human osteoclast precursor and prevents joint damage in a collagen-induced murin arthritis model
- Title
- Poly-γ-glutamic acid suppresses osteoclastogenesis in human osteoclast precursor and prevents joint damage in a collagen-induced murin arthritis model
- Author
- 조성신
- Keywords
- Poly-gamma-glutamic acid (gamma-PGA); Osteoclast; Rheumatoid arthritis
- Issue Date
- 2018-11
- Publisher
- ELSEVIER SCIENCE BV
- Citation
- IMMUNOLOGY LETTERS, v. 203, page. 80-86
- Abstract
- Poly-gamma-glutamic acid (gamma-PGA), a natural polymer derived from Bacillus subtilis, shows anti-inflammatory activity. However, the effects of gamma-PGA on osteoclasts, which are important cells for joint destruction in inflammatory diseases such as rheumatoid arthritis (RA), have not yet been reported. In this study, we show that gamma-PGA markedly inhibits osteoclast differentiation in normal PBMC-derived osteoclast precursors and in synovial fluid macrophages of patients with RA. gamma-PGA also reduces RANK expression by down-regulating M-CSF receptors. Additionally, oral administration of gamma-PGA attenuated bone destruction in a collagen-induced arthritis (CIA) model, demonstrating decreases in inflammation, cartilage damage, and osteoclast formation in histological analyses. Taken together, these data suggest that gamma-PGA could be a good candidate for therapeutic prevention of joint destruction in RA.
- URI
- https://linkinghub.elsevier.com/retrieve/pii/S0165247818302104https://repository.hanyang.ac.kr/handle/20.500.11754/120763
- ISSN
- 0165-2478; 1879-0542
- DOI
- 10.1016/j.imlet.2018.09.004
- Appears in Collections:
- RESEARCH INSTITUTE[S](부설연구소) > ETC
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