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dc.contributor.author조성신-
dc.date.accessioned2019-12-10T05:18:13Z-
dc.date.available2019-12-10T05:18:13Z-
dc.date.issued2018-11-
dc.identifier.citationIMMUNOLOGY LETTERS, v. 203, page. 80-86en_US
dc.identifier.issn0165-2478-
dc.identifier.issn1879-0542-
dc.identifier.urihttps://linkinghub.elsevier.com/retrieve/pii/S0165247818302104-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/120763-
dc.description.abstractPoly-gamma-glutamic acid (gamma-PGA), a natural polymer derived from Bacillus subtilis, shows anti-inflammatory activity. However, the effects of gamma-PGA on osteoclasts, which are important cells for joint destruction in inflammatory diseases such as rheumatoid arthritis (RA), have not yet been reported. In this study, we show that gamma-PGA markedly inhibits osteoclast differentiation in normal PBMC-derived osteoclast precursors and in synovial fluid macrophages of patients with RA. gamma-PGA also reduces RANK expression by down-regulating M-CSF receptors. Additionally, oral administration of gamma-PGA attenuated bone destruction in a collagen-induced arthritis (CIA) model, demonstrating decreases in inflammation, cartilage damage, and osteoclast formation in histological analyses. Taken together, these data suggest that gamma-PGA could be a good candidate for therapeutic prevention of joint destruction in RA.en_US
dc.description.sponsorshipThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (2013R1A1A2009617) and the Ministry of Science, ICT, & Future (2016R1A2B4008606), and a grant of the Korea Health Technology R&D project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI17C0888 and HI15C1062). We thank Dr. Dong Soo Han (Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Korea) for providing experimental materials.en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectPoly-gamma-glutamic acid (gamma-PGA)en_US
dc.subjectOsteoclasten_US
dc.subjectRheumatoid arthritisen_US
dc.titlePoly-γ-glutamic acid suppresses osteoclastogenesis in human osteoclast precursor and prevents joint damage in a collagen-induced murin arthritis modelen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.imlet.2018.09.004-
dc.relation.page80-86-
dc.relation.journalIMMUNOLOGY LETTERS-
dc.contributor.googleauthorLee, Bitnara-
dc.contributor.googleauthorJo, Sungsin-
dc.contributor.googleauthorKim, Sung-Min-
dc.contributor.googleauthorCho, Mi-La-
dc.contributor.googleauthorPark, Sung-Hwan-
dc.contributor.googleauthorYoun, Jeehee-
dc.contributor.googleauthorJi, Jong Dae-
dc.contributor.googleauthorKim, Tae-Hwan-
dc.relation.code2018012373-
dc.sector.campusS-
dc.sector.daehakRESEARCH INSTITUTE[S]-
dc.sector.departmentRHEUMATISM CENTER-
dc.identifier.pidjoejo0517-
dc.identifier.orcidhttp://orcid.org/0000-0003-3034-5029-
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