Senotherapy for attenuation of cellular senescence in aging and organ implantation
- Title
- Senotherapy for attenuation of cellular senescence in aging and organ implantation
- Author
- 이동윤
- Keywords
- Cellular senescence; Transplantation; Senolytic agent; Aging; Senescence-associated secretory phenotype
- Issue Date
- 2018-04
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 60, page. 1-8
- Abstract
- Cellular senescence in transplant is induced by aging and therapy-induced stress, which is caused by generation of senescent cells in transplant during engraftment. These senescent cells induce transplant failure due to secretion of senescence-associated secretory phenotype (SASP). So, elimination of senescent cells in transplant is important for successful comes. Recently, numerous studies have focused on the development of various senolytic agents such as dasatinib, quercetin, and navitoclax according to cellular type of transplant. Therefore, this study reviews the influence of cellular senescence in transplantation and capacity of senolytic agents as a new therapeutic strategy for successful outcomes of transplant.
- URI
- https://www.sciencedirect.com/science/article/pii/S1226086X17304720?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/118374
- ISSN
- 1226-086X; 1876-794X
- DOI
- 10.1016/j.jiec.2017.08.053
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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