Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이동윤 | - |
dc.date.accessioned | 2019-12-07T19:51:37Z | - |
dc.date.available | 2019-12-07T19:51:37Z | - |
dc.date.issued | 2018-04 | - |
dc.identifier.citation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 60, page. 1-8 | en_US |
dc.identifier.issn | 1226-086X | - |
dc.identifier.issn | 1876-794X | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1226086X17304720?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/118374 | - |
dc.description.abstract | Cellular senescence in transplant is induced by aging and therapy-induced stress, which is caused by generation of senescent cells in transplant during engraftment. These senescent cells induce transplant failure due to secretion of senescence-associated secretory phenotype (SASP). So, elimination of senescent cells in transplant is important for successful comes. Recently, numerous studies have focused on the development of various senolytic agents such as dasatinib, quercetin, and navitoclax according to cellular type of transplant. Therefore, this study reviews the influence of cellular senescence in transplantation and capacity of senolytic agents as a new therapeutic strategy for successful outcomes of transplant. | en_US |
dc.description.sponsorship | This study was supported by Basic Science Research Program (NRF-2015R1A2A1A05001832) and partially by the Bio & Medical Technology Development Program (NRF-2015M3A9E2030125) through the National Research Foundation (NRF) funded by the Korean Government (MSIP & MOHW). Also, this study was partially supported by a grant of the Korea Health Technology R&D project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI14C2099). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.subject | Cellular senescence | en_US |
dc.subject | Transplantation | en_US |
dc.subject | Senolytic agent | en_US |
dc.subject | Aging | en_US |
dc.subject | Senescence-associated secretory phenotype | en_US |
dc.title | Senotherapy for attenuation of cellular senescence in aging and organ implantation | en_US |
dc.type | Article | en_US |
dc.relation.volume | 60 | - |
dc.identifier.doi | 10.1016/j.jiec.2017.08.053 | - |
dc.relation.page | 1-8 | - |
dc.relation.journal | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.contributor.googleauthor | Kang, Dong Hoon | - |
dc.contributor.googleauthor | Park, Yeon Soo | - |
dc.contributor.googleauthor | Lee, Dong Yun | - |
dc.relation.code | 2018007973 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | dongyunlee | - |
dc.identifier.orcid | http://orcid.org/0000-0001-7691-0447 | - |
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