The antidepressant action of 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid is mediated by phosphorylation of histone deacetylase 5
- Title
- The antidepressant action of 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid is mediated by phosphorylation of histone deacetylase 5
- Author
- 김용석
- Keywords
- Depression; Hippocampus; Histone deacetylase 5; NMDA receptor antagonist; Phosphorylation
- Issue Date
- 2018-03
- Publisher
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Citation
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v. 22, no. 2, page. 155-162
- Abstract
- 3-(2-Carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP), a competitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid antidepressant-like effects in animal models of depression. However, the molecular mechanisms underlying these behavioral actions remain unknown. Here, we demonstrate that CPP rapidly stimulates histone deacetylase (HDAC) 5 phosphorylation and nuclear export in rat hippocampal neurons. These effects are accompanied by calcium/calmodulin kinase II (CaMKII) and protein kinase D (PKD) phosphorylation. Behavioral experiments revealed that viral-mediated hippocampal knockdown of HDAC5 blocked the antidepressant effects of CPP in stressed animals. Taken together, our results imply that CPP acts via HDAC5 and suggest that HDAC5 is a common regulator contributing to the antidepressant actions of NMDA receptor antagonists such as CPP.
- URI
- https://synapse.koreamed.org/DOIx.php?id=10.4196/kjpp.2018.22.2.155https://repository.hanyang.ac.kr/handle/20.500.11754/118010
- ISSN
- 1226-4512; 2093-3827
- DOI
- 10.4196/kjpp.2018.22.2.155
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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