Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김용석 | - |
dc.date.accessioned | 2019-12-06T07:57:03Z | - |
dc.date.available | 2019-12-06T07:57:03Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.citation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v. 22, no. 2, page. 155-162 | en_US |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4196/kjpp.2018.22.2.155 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/118010 | - |
dc.description.abstract | 3-(2-Carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP), a competitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid antidepressant-like effects in animal models of depression. However, the molecular mechanisms underlying these behavioral actions remain unknown. Here, we demonstrate that CPP rapidly stimulates histone deacetylase (HDAC) 5 phosphorylation and nuclear export in rat hippocampal neurons. These effects are accompanied by calcium/calmodulin kinase II (CaMKII) and protein kinase D (PKD) phosphorylation. Behavioral experiments revealed that viral-mediated hippocampal knockdown of HDAC5 blocked the antidepressant effects of CPP in stressed animals. Taken together, our results imply that CPP acts via HDAC5 and suggest that HDAC5 is a common regulator contributing to the antidepressant actions of NMDA receptor antagonists such as CPP. | en_US |
dc.description.sponsorship | This work was supported by National Research Foundation of Korea (NRF) grant (No. 2016R1A2B2006474; H.S.), Basic Science Research Program (No. 2016R1A6A3A01007757; M.Y.C) and Medical Research Center (2017R1A5A2015395; H.S.) funded by the NRF of the Ministry of Science and Technology (MEST), Republic of Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | en_US |
dc.subject | Depression | en_US |
dc.subject | Hippocampus | en_US |
dc.subject | Histone deacetylase 5 | en_US |
dc.subject | NMDA receptor antagonist | en_US |
dc.subject | Phosphorylation | en_US |
dc.title | The antidepressant action of 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid is mediated by phosphorylation of histone deacetylase 5 | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 22 | - |
dc.identifier.doi | 10.4196/kjpp.2018.22.2.155 | - |
dc.relation.page | 155-162 | - |
dc.relation.journal | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.contributor.googleauthor | Park, Min Hyeop | - |
dc.contributor.googleauthor | Choi, Miyeon | - |
dc.contributor.googleauthor | Kim, Yong-Seok | - |
dc.contributor.googleauthor | Son, Hyeon | - |
dc.relation.code | 2018004103 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | yongsk | - |
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