Evaluation of anti-diabetic activity of glycyrrhizin-loaded nanoparticles in nicotinamide-streptozotocin-induced diabetic rats
- Title
- Evaluation of anti-diabetic activity of glycyrrhizin-loaded nanoparticles in nicotinamide-streptozotocin-induced diabetic rats
- Author
- 김기현
- Keywords
- Ionotropic gelation; Nanoparticles; Sustained release; Anti-diabetic effect; Blood glucose level; Lipid profile; Glycosylated hemoglobin
- Issue Date
- 2017-08
- Publisher
- ELSEVIER SCIENCE BV
- Citation
- EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, v. 106, page. 220-230
- Abstract
- Glycyrrhizin is an active constituent of the roots and rhizomes of Glycyrrhiza glabra and has anti-hyperglycemic effects. In this study, nanoparticles (NPs) loaded with glycyrrhizin or metformin were evaluated in vivo for their anti-hyperglycemic potency towards type-II diabetes in rats. The NPs were produced via the ionotropic gelation method using the biocompatible polymers chitosan and gum arabic. The polymer concentration was optimized using the 3(2) factorial method to acquire both minimum particle size and maximum encapsulation efficiency. The NPs were then characterized with respect to particle size, encapsulation efficiency, stability, chemical interactions, and in vitro drug dissolution profiles using spectroscopic and microscopic analysis. Furthermore, glycyrrhizin and metformin and their nanoformulations were administered for 21 successive days to diabetic rats. Glycyrrhizin-loaded NPs had significant anti-diabetic effects even though they contained approximately one quarter of the dosage relative to the pure form.
- URI
- https://www.sciencedirect.com/science/article/pii/S0928098717303202?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/115336
- ISSN
- 0928-0987; 1879-0720
- DOI
- 10.1016/j.ejps.2017.05.068
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > CIVIL AND ENVIRONMENTAL ENGINEERING(건설환경공학과) > Articles
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