Development of a Paper-Based Viscometer for Blood Plasma Using Colorimetric Analysis
- Title
- Development of a Paper-Based Viscometer for Blood Plasma Using Colorimetric Analysis
- Author
- 송시몬
- Keywords
- MICROFLUIDIC VISCOMETER; ANALYTICAL DEVICE; SURFACE-TENSION; VISCOSITY; FLOW; POINT; CONSTITUENTS; DYNAMICS; CHANNEL; SERUM
- Issue Date
- 2019-04
- Publisher
- AMER CHEMICAL SOC
- Citation
- ANALYTICAL CHEMISTRY, v. 91, NO 7, Page. 4868-4875
- Abstract
- The viscosity of biofluids can be used to acquire meaningful medical information on the conditions of a patient but has seldom been utilized in clinical practices owing to cumbersome measurement procedures and the need for large sample volumes. We present a colorimetric method to measure the viscosity of blood plasma using a paper-based viscometer developed in this study specifically for clinical diagnosis. The proposed analytical device consists of multilayered papers with fluid-loading -mixing, and-measuring regions, and it can be fabricated readily in a simple manner using three-layered paper channels and tape. Moreover, the colorimetric analysis enables viscosity estimations by analyzing a single optical image. To validate the device performance, we measured the viscosities of fluids such as glycerin aqueous solutions, bovine-serum-albumin solution, dimethyl sulfoxide, and blood plasma. We found that the measured viscosities were in good agreement with the reference values. Finally, we developed a simple smartphone application for the viscosity measurements that helped enhance the convenience and utility of the paper-based viscometer while maintaining the measurement accuracy.
- URI
- https://pubs.acs.org/doi/10.1021/acs.analchem.9b00624https://repository.hanyang.ac.kr/handle/20.500.11754/110951
- ISSN
- 0003-2700; 1520-6882
- DOI
- 10.1021/acs.analchem.9b00624
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > MECHANICAL ENGINEERING(기계공학부) > Articles
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