Mismatch Negativity and Cortical Thickness in Patients With Schizophrenia and Bipolar Disorder
- Title
- Mismatch Negativity and Cortical Thickness in Patients With Schizophrenia and Bipolar Disorder
- Author
- 임창환
- Keywords
- mismatch negativity; cortical thickness; schizophrenia; bipolar disorder
- Issue Date
- 2019-03
- Publisher
- OXFORD UNIV PRESS
- Citation
- SCHIZOPHRENIA BULLETIN, v. 45, NO 2, Page. 425-435
- Abstract
- Introduction Mismatch negativity (MMN) is a measure of automatic neurophysiological brain processes for detecting unexpected sensory stimuli. This study investigated MMN reduction in patients with schizophrenia and bipolar disorder and examined whether cortical thickness is associated with MMN, for exploratory purposes.
Methods Electroencephalograms were recorded in 38 patients with schizophrenia, 37 patients with bipolar disorder, and 32 healthy controls (HCs) performing a passive auditory oddball paradigm. All participants underwent T1 structural magnetic resonance imaging scanning to investigate the cortical thickness of MMN-generating regions. Average MMN amplitudes from the frontocentral electrodes were analyzed.
Results Patients with schizophrenia and bipolar disorder exhibited significantly reduced MMN amplitude compared with HCs. In bipolar disorder, we found intermediate MMN amplitude among the groups. Average MMN and cortical thickness of the right superior temporal gyrus (STG) were significantly negatively correlated in patients with schizophrenia. In patients with bipolar disorder, average MMN was significantly correlated with cortical thickness of the left anterior cingulate cortex and the right STG. MMN showed negative correlations with social and occupational functioning in schizophrenia, and with the Korean auditory verbal learning test for delayed recall in bipolar disorder.
Conclusions MMN reduction was associated with cortical thinning in frontal and temporal areas in patients, particularly with an auditory verbal hallucination-related region in schizophrenia and emotion-related regions in bipolar disorder. MMN was associated with functional outcomes in schizophrenia, whereas it was associated with neurocognition in bipolar disorder.
- URI
- https://academic.oup.com/schizophreniabulletin/article/45/2/425/4978295https://repository.hanyang.ac.kr/handle/20.500.11754/110791
- ISSN
- 0586-7614; 1745-1701
- DOI
- 10.1093/schbul/sby041
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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