Development of apoptosis-inducing polypeptide via simultaneous mitochondrial membrane disruption and Ca2+ delivery
- Title
- Development of apoptosis-inducing polypeptide via simultaneous mitochondrial membrane disruption and Ca2+ delivery
- Author
- 윤채옥
- Keywords
- Mitochondrial membrane destabilization; Calcium ion delivery; Pro-apoptotic activity; Anti-cancer polypeptide
- Issue Date
- 2019-03
- Publisher
- ELSEVIER SCI LTD
- Citation
- BIOMATERIALS, v. 197, Page. 51-59
- Abstract
- Mitochondria are the primary organelle of regulating apoptosis, and intracellular calcium ions are a key component of pro-apoptosis induction. Herein, we report an artificial apoptosis-inducing polypeptide that destabilizes the mitochondrial membrane and transports calcium ions into the cytosol, thereby synergistically creating severe oxidative conditions. The oxidative stress highly activates an apoptotic signaling cascade, and also inhibits cell migration and invasion in vitro and in vivo. The suggested strategy for simultaneous mitochondrial disruption and perturbed calcium homeostasis demonstrates the applicability of polypeptide-based therapeutics as potent apoptosis-inducers in cancer therapy.
- URI
- https://www.sciencedirect.com/science/article/pii/S0142961219300067?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/110432
- ISSN
- 0142-9612; 1878-5905
- DOI
- 10.1016/j.biomaterials.2019.01.006
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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