Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2019-09-16T02:43:15Z | - |
dc.date.available | 2019-09-16T02:43:15Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | BIOMATERIALS, v. 197, Page. 51-59 | en_US |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0142961219300067?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/110432 | - |
dc.description.abstract | Mitochondria are the primary organelle of regulating apoptosis, and intracellular calcium ions are a key component of pro-apoptosis induction. Herein, we report an artificial apoptosis-inducing polypeptide that destabilizes the mitochondrial membrane and transports calcium ions into the cytosol, thereby synergistically creating severe oxidative conditions. The oxidative stress highly activates an apoptotic signaling cascade, and also inhibits cell migration and invasion in vitro and in vivo. The suggested strategy for simultaneous mitochondrial disruption and perturbed calcium homeostasis demonstrates the applicability of polypeptide-based therapeutics as potent apoptosis-inducers in cancer therapy. | en_US |
dc.description.sponsorship | This work was financially supported by the Ministry of Science and ICT of Korea (Project No. NRF-2014M3A9E4064580, NRF-2016R1A2B4009619, NRF-2018M3A9E2024583 to Y.C. Kim; NRF-2016M3A9B594235 to C.O. Yun) and the Animal and Plant Quarantine Agency, Gimcheon, Gyenongsangbuk-do, Republic of Korea (N04130146). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.subject | Mitochondrial membrane destabilization | en_US |
dc.subject | Calcium ion delivery | en_US |
dc.subject | Pro-apoptotic activity | en_US |
dc.subject | Anti-cancer polypeptide | en_US |
dc.title | Development of apoptosis-inducing polypeptide via simultaneous mitochondrial membrane disruption and Ca2+ delivery | en_US |
dc.type | Article | en_US |
dc.relation.volume | 197 | - |
dc.identifier.doi | 10.1016/j.biomaterials.2019.01.006 | - |
dc.relation.page | 51-59 | - |
dc.relation.journal | BIOMATERIALS | - |
dc.contributor.googleauthor | Ha, JongHoon | - |
dc.contributor.googleauthor | Lee, DaeYong | - |
dc.contributor.googleauthor | Lee, Soo-Hwan | - |
dc.contributor.googleauthor | Yun, Chae-Ok | - |
dc.contributor.googleauthor | Kim, Yeu-Chun | - |
dc.relation.code | 2019000362 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | chaeok | - |
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