HPLC method for the pharmacokinetics study of acemetacin in human plasma
- Title
- HPLC method for the pharmacokinetics study of acemetacin in human plasma
- Author
- 김진기
- Keywords
- acemetacin; indometacin; high performance liquid chromatography (HPLC)
- Issue Date
- 2005-02
- Publisher
- TAYLOR & FRANCIS INC
- Citation
- JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, v. 28, No. 10, Page. 1593-1604
- Abstract
- A reproducible and specific high performance liquid chromatography (HPLC) method was developed to quantity plasma levels of acemetacin and its metabolite, indometacin in order to conduct a pharmacokinetics study. Plasma samples were prepared by liquid-liquid extraction using ethyl acetate.- Extracted samples were analyzed on a reverse-phase C-18 column with a mobile phase consisting of 20mM phosphate buffer (pH 2.9) and acetonitrile (60:40, v/v) and UV detection at 254nm. Using this method, the phannacokinctics study was carried out on eight volunteers after a single oral administration.
- URI
- https://www.tandfonline.com/doi/full/10.1081/JLC-200058377https://repository.hanyang.ac.kr/handle/20.500.11754/110200
- ISSN
- 1082-6076
- DOI
- 10.1081/JLC-200058377
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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