Long-acting anticholinergic agents in patients with uncontrolled asthma: a systematic review and meta-analysis
- Title
- Long-acting anticholinergic agents in patients with uncontrolled asthma: a systematic review and meta-analysis
- Author
- 문지용
- Keywords
- asthma; tiotropium; anticholinergics
- Issue Date
- 2014-12
- Publisher
- INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
- Citation
- INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 권: 18, 호: 12, 페이지: 1421-1430
- Abstract
- SETTING: A novel effective treatment is necessary for severe asthma. OBJECTIVE: To review clinical trials examining the role of tiotropium in patients with poorly controlled asthma despite inhaled corticosteroid use with or without long-acting beta(2)-agonists. DESIGN: A computerised search of electronic databases (Medline, EMBASE and Cochrane Central Register) was performed. Randomised controlled trials of at least a 4-week treatment duration with findings published in English were included. RESULTS: Five studies involving 1635 patients were analysed. Compared with a placebo or a double dose of inhaled corticosteroids, the addition of tiotropium increased mean trough and peak forced expiratory volume in 1 second by 97 ml (95%Cl 71-122) and 103 ml (95%CI 42-163), respectively. The mean differences in morning peak expiratory flow were 19.2 I/min (95%CI 11.8-26.6). Tiotropium also reduced the risk of severe acute exacerbation (OR 0.73, 95%CI 0.56-0.96) and improved Asthma Quality-of-Life Questionnaire score significantly by 0.10 (95 %Cl 0.04-0.16). There were no differences in serious adverse events. CONCLUSION: The addition of tiotropium may be beneficial for patients with poorly controlled asthma, although exacerbation or safety issues should be clarified in long-term trials before its wide use in asthma.
- URI
- http://www.ingentaconnect.com/content/iuatld/ijtld/2014/00000018/00000012/art00008;jsessionid=3a734pbvmu9em.x-ic-live-02#http://hdl.handle.net/20.500.11754/52720
- ISSN
- 1027-3719; 1815-7920
- DOI
- 10.5588/ijtld.14.0275
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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