Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 문지용 | - |
dc.date.accessioned | 2018-03-26T13:47:52Z | - |
dc.date.available | 2018-03-26T13:47:52Z | - |
dc.date.issued | 2014-12 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 권: 18, 호: 12, 페이지: 1421-1430 | en_US |
dc.identifier.issn | 1027-3719 | - |
dc.identifier.issn | 1815-7920 | - |
dc.identifier.uri | http://www.ingentaconnect.com/content/iuatld/ijtld/2014/00000018/00000012/art00008;jsessionid=3a734pbvmu9em.x-ic-live-02# | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/52720 | - |
dc.description.abstract | SETTING: A novel effective treatment is necessary for severe asthma. OBJECTIVE: To review clinical trials examining the role of tiotropium in patients with poorly controlled asthma despite inhaled corticosteroid use with or without long-acting beta(2)-agonists. DESIGN: A computerised search of electronic databases (Medline, EMBASE and Cochrane Central Register) was performed. Randomised controlled trials of at least a 4-week treatment duration with findings published in English were included. RESULTS: Five studies involving 1635 patients were analysed. Compared with a placebo or a double dose of inhaled corticosteroids, the addition of tiotropium increased mean trough and peak forced expiratory volume in 1 second by 97 ml (95%Cl 71-122) and 103 ml (95%CI 42-163), respectively. The mean differences in morning peak expiratory flow were 19.2 I/min (95%CI 11.8-26.6). Tiotropium also reduced the risk of severe acute exacerbation (OR 0.73, 95%CI 0.56-0.96) and improved Asthma Quality-of-Life Questionnaire score significantly by 0.10 (95 %Cl 0.04-0.16). There were no differences in serious adverse events. CONCLUSION: The addition of tiotropium may be beneficial for patients with poorly controlled asthma, although exacerbation or safety issues should be clarified in long-term trials before its wide use in asthma. | en_US |
dc.description.sponsorship | This study was supported by a grant of the National Strategic Coordinating Center for Clinical Research, Ministry for Health & Welfare Affairs, Republic of Korea (HI10C2020). The funding sources had no role in study design, data collection and analysis, manuscript preparation, or the decision to submit the manuscript for publication. | en_US |
dc.language.iso | en | en_US |
dc.publisher | INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | en_US |
dc.subject | asthma | en_US |
dc.subject | tiotropium | en_US |
dc.subject | anticholinergics | en_US |
dc.title | Long-acting anticholinergic agents in patients with uncontrolled asthma: a systematic review and meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 12 | - |
dc.relation.volume | 18 | - |
dc.identifier.doi | 10.5588/ijtld.14.0275 | - |
dc.relation.page | 1421-1430 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | - |
dc.contributor.googleauthor | Lee, S. W. | - |
dc.contributor.googleauthor | Kim, H. J. | - |
dc.contributor.googleauthor | Yoo, K. H. | - |
dc.contributor.googleauthor | Park, Y. B. | - |
dc.contributor.googleauthor | Park, J-Y. | - |
dc.contributor.googleauthor | Jung, J. Y. | - |
dc.contributor.googleauthor | Moon, J-Y. | - |
dc.contributor.googleauthor | Byun, M. K. | - |
dc.contributor.googleauthor | Kim, S. W. | - |
dc.contributor.googleauthor | Kim, Y. H. | - |
dc.relation.code | 2014031833 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | moonji | - |
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