Rheumatoid fibroblast-like synoviocytes downregulate Foxp3 expression by regulatory T cells via GITRL/GITR interaction
- Title
- Rheumatoid fibroblast-like synoviocytes downregulate Foxp3 expression by regulatory T cells via GITRL/GITR interaction
- Other Titles
- GITR interaction
- Author
- 윤지희
- Keywords
- Autoimmune arthritis; Regulatory T cells; Fibroblast-like synoviocytes; Foxp3
- Issue Date
- 2012-10
- Publisher
- 대한면역학회 / The Korean Association of Immunologists
- Citation
- Immune Network, 2012, 12(5), P.217-221
- Abstract
- Fibroblast-like synoviocytes (FLS) colocalize with leukocyte infiltrates in rheumatoid synovia. Proinflammatory leukocytes are known to amplify inflammation by signaling to FLS, but crosstalk between FLS and regulatory T cells (Tregs) remains uncharacterized. To address this possibility, we cocultured FLS lines derived from arthritic mice with Tregs. FLS that expressed the ligand for glucocorticoid-induced TNF receptor family-related gene (GITR) decreased expression of Foxp3 and GITR in Tregs in a contact-dependent manner. This effect was abolished by blocking antibody to GITR. On the other hand, the Tregs caused the FLS to increase IL-6 production. These results demonstrate that inflamed FLS license Tregs to downregulate Foxp3 expression via the GITRL/GITR interaction while the Tregs induce the FLS to increase their production of IL-6. Our findings suggest that the interaction between FLS and Tregs dampens the anti-inflammatory activity of Tregs and amplifies the proinflammatory activity of FLS, thereby exacerbating inflammatory arthritis.
- URI
- https://synapse.koreamed.org/DOIx.php?id=10.4110/in.2012.12.5.217http://hdl.handle.net/20.500.11754/50183
- ISSN
- 1598-2629; 2092-6685
- DOI
- 10.4110/in.2012.12.5.217
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
- in-12-217.pdfDownload
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