Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤지희 | - |
dc.date.accessioned | 2018-03-21T08:26:19Z | - |
dc.date.available | 2018-03-21T08:26:19Z | - |
dc.date.issued | 2012-10 | - |
dc.identifier.citation | Immune Network, 2012, 12(5), P.217-221 | en_US |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.issn | 2092-6685 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4110/in.2012.12.5.217 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/50183 | - |
dc.description.abstract | Fibroblast-like synoviocytes (FLS) colocalize with leukocyte infiltrates in rheumatoid synovia. Proinflammatory leukocytes are known to amplify inflammation by signaling to FLS, but crosstalk between FLS and regulatory T cells (Tregs) remains uncharacterized. To address this possibility, we cocultured FLS lines derived from arthritic mice with Tregs. FLS that expressed the ligand for glucocorticoid-induced TNF receptor family-related gene (GITR) decreased expression of Foxp3 and GITR in Tregs in a contact-dependent manner. This effect was abolished by blocking antibody to GITR. On the other hand, the Tregs caused the FLS to increase IL-6 production. These results demonstrate that inflamed FLS license Tregs to downregulate Foxp3 expression via the GITRL/GITR interaction while the Tregs induce the FLS to increase their production of IL-6. Our findings suggest that the interaction between FLS and Tregs dampens the anti-inflammatory activity of Tregs and amplifies the proinflammatory activity of FLS, thereby exacerbating inflammatory arthritis. | en_US |
dc.language.iso | en | en_US |
dc.publisher | 대한면역학회 / The Korean Association of Immunologists | en_US |
dc.subject | Autoimmune arthritis | en_US |
dc.subject | Regulatory T cells | en_US |
dc.subject | Fibroblast-like synoviocytes | en_US |
dc.subject | Foxp3 | en_US |
dc.title | Rheumatoid fibroblast-like synoviocytes downregulate Foxp3 expression by regulatory T cells via GITRL/GITR interaction | en_US |
dc.title.alternative | GITR interaction | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 12 | - |
dc.identifier.doi | 10.4110/in.2012.12.5.217 | - |
dc.relation.page | 217-221 | - |
dc.relation.journal | Immune Network | - |
dc.contributor.googleauthor | Kim, Sung-Hoon | - |
dc.contributor.googleauthor | Youn, Jee-Hee | - |
dc.relation.code | 2012220830 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jhyoun | - |
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