Comparison of polyphenol-rich wine grape seed flour-regulated fecal and blood microRNAs in high-fat, high-fructose diet-induced obese mice
- Title
- Comparison of polyphenol-rich wine grape seed flour-regulated fecal and blood microRNAs in high-fat, high-fructose diet-induced obese mice
- Author
- Hyunsook Kim
- Keywords
- miRNA biomarker; Obesity; Feces; Blood; Polyphenol
- Issue Date
- 2020-10
- Publisher
- ELSEVIER
- Citation
- JOURNAL OF FUNCTIONAL FOODS, v. 73, article no. 104147, page. 1-7
- Abstract
- A biomarker, easily and noninvasively measured in feces, can be useful in monitoring efficacy of novel functional foods against complicated pathologies of obesity-related metabolic diseases. Fecal microRNA (miRNA)s were analyzed for potential noninvasive biomarkers in C57BL/6J mice fed a high-fat and high-fructose diet (HFrD) containing either microcrystalline cellulose (MCC) or 5% polyphenol-rich wine grape seed flour (GSF) for 8 weeks. GSF supplementation significantly reduced HFrD-induced body weight gain, visceral adiposity, and hyperlipidemia. miRNome analysis revealed that GSF supplementation significantly (p < 0.05; fold-change, vertical bar FC vertical bar >= 1.5) regulated 82 and 4 miRNAs in the feces and blood, respectively. Among these miRNAs, 22 in feces and 4 in blood were strongly associated with obesity-related physiological biomarkers, and miR-129-5p in both blood and feces showed a strong correlation with obesity-related biomarkers. These results suggest that fecal miR-129-5p is a potentially useful noninvasive biomarker in monitoring personalized GSF efficacy against obesity and obesity-metabolic disease.
- URI
- https://www.sciencedirect.com/science/article/pii/S1756464620303716?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/172055
- ISSN
- 1756-4646; 2214-9414
- DOI
- 10.1016/j.jff.2020.104147
- Appears in Collections:
- COLLEGE OF HUMAN ECOLOGY[S](생활과학대학) > FOOD & NUTRITION(식품영양학과) > Articles
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