Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyunsook Kim | - |
dc.date.accessioned | 2022-08-03T06:28:49Z | - |
dc.date.available | 2022-08-03T06:28:49Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.citation | JOURNAL OF FUNCTIONAL FOODS, v. 73, article no. 104147, page. 1-7 | en_US |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.issn | 2214-9414 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1756464620303716?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/172055 | - |
dc.description.abstract | A biomarker, easily and noninvasively measured in feces, can be useful in monitoring efficacy of novel functional foods against complicated pathologies of obesity-related metabolic diseases. Fecal microRNA (miRNA)s were analyzed for potential noninvasive biomarkers in C57BL/6J mice fed a high-fat and high-fructose diet (HFrD) containing either microcrystalline cellulose (MCC) or 5% polyphenol-rich wine grape seed flour (GSF) for 8 weeks. GSF supplementation significantly reduced HFrD-induced body weight gain, visceral adiposity, and hyperlipidemia. miRNome analysis revealed that GSF supplementation significantly (p < 0.05; fold-change, vertical bar FC vertical bar >= 1.5) regulated 82 and 4 miRNAs in the feces and blood, respectively. Among these miRNAs, 22 in feces and 4 in blood were strongly associated with obesity-related physiological biomarkers, and miR-129-5p in both blood and feces showed a strong correlation with obesity-related biomarkers. These results suggest that fecal miR-129-5p is a potentially useful noninvasive biomarker in monitoring personalized GSF efficacy against obesity and obesity-metabolic disease. | en_US |
dc.description.sponsorship | This study was supported by a grant from the National Research Foundation of Korea (NRF), funded by the Korean government (MSIP) (Grant number, 2018R1A2B6001097). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER | en_US |
dc.subject | miRNA biomarker | en_US |
dc.subject | Obesity | en_US |
dc.subject | Feces | en_US |
dc.subject | Blood | en_US |
dc.subject | Polyphenol | en_US |
dc.title | Comparison of polyphenol-rich wine grape seed flour-regulated fecal and blood microRNAs in high-fat, high-fructose diet-induced obese mice | en_US |
dc.type | Article | en_US |
dc.relation.volume | 73 | - |
dc.identifier.doi | 10.1016/j.jff.2020.104147 | - |
dc.relation.page | 1-7 | - |
dc.relation.journal | JOURNAL OF FUNCTIONAL FOODS | - |
dc.contributor.googleauthor | Seo, Kun-Ho | - |
dc.contributor.googleauthor | Yokoyama, Wallace | - |
dc.contributor.googleauthor | Kim, Hyunsook | - |
dc.relation.code | 2020048223 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | hyunsk15 | - |
dc.identifier.orcid | https://orcid.org/0000-0001-7345-4167 | - |
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