Heterogenous Effect of Risk Factors on Breast Cancer across the Breast Density Categories in a Korean Screening Population
- Title
- Heterogenous Effect of Risk Factors on Breast Cancer across the Breast Density Categories in a Korean Screening Population
- Author
- 박보영
- Keywords
- breast cancer; Breast Imaging-Reporting and Data System; breast density; risk factors; heterogeneous effect
- Issue Date
- 2020-05
- Publisher
- MDPI
- Citation
- CANCERS, v. 12, no. 6, article no. 1391
- Abstract
- We evaluated the heterogeneity of the effect of known risk factors on breast cancer development based on breast density by using the Breast Imaging-Reporting and Data System (BI-RADS). In total, 4,898,880 women, aged 40–74 years, who participated in the national breast cancer screening program in 2009–2010 were followed up to December 2018. Increased age showed a heterogeneous association with breast cancer (1-year hazard ratio (HR) = 0.92, 1.00 (reference), 1.03, and 1.03 in women with BI-RADS density category 1, 2, 3, and 4, respectively; P-heterogeneity < 0.001). More advanced age at menopause increased breast cancer risk in all BI-RADS categories. This was more prominent in women with BI-RADS density category 1 but less prominent in women in other BI-RADS categories (P-heterogeneity = 0.009). In postmenopausal women, a family history of breast cancer, body mass index ≥ 25 kg/m2, and smoking showed a heterogeneous association with breast cancer across all BI-RADS categories. Other risk factors including age at menarche, menopause, hormone replacement therapy after menopause, oral contraceptive use, and alcohol consumption did not show a heterogeneous association with breast cancer across the BI-RADS categories. Several known risk factors of breast cancer had a heterogeneous effect on breast cancer development across breast density categories, especially in postmenopausal women.
- URI
- https://www.mdpi.com/2072-6694/12/6/1391https://repository.hanyang.ac.kr/handle/20.500.11754/166235
- ISSN
- 2072-6694
- DOI
- 10.3390/cancers12061391
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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