Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박보영 | - |
dc.date.accessioned | 2021-11-15T04:39:44Z | - |
dc.date.available | 2021-11-15T04:39:44Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.citation | CANCERS, v. 12, no. 6, article no. 1391 | en_US |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | https://www.mdpi.com/2072-6694/12/6/1391 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/166235 | - |
dc.description.abstract | We evaluated the heterogeneity of the effect of known risk factors on breast cancer development based on breast density by using the Breast Imaging-Reporting and Data System (BI-RADS). In total, 4,898,880 women, aged 40–74 years, who participated in the national breast cancer screening program in 2009–2010 were followed up to December 2018. Increased age showed a heterogeneous association with breast cancer (1-year hazard ratio (HR) = 0.92, 1.00 (reference), 1.03, and 1.03 in women with BI-RADS density category 1, 2, 3, and 4, respectively; P-heterogeneity < 0.001). More advanced age at menopause increased breast cancer risk in all BI-RADS categories. This was more prominent in women with BI-RADS density category 1 but less prominent in women in other BI-RADS categories (P-heterogeneity = 0.009). In postmenopausal women, a family history of breast cancer, body mass index ≥ 25 kg/m2, and smoking showed a heterogeneous association with breast cancer across all BI-RADS categories. Other risk factors including age at menarche, menopause, hormone replacement therapy after menopause, oral contraceptive use, and alcohol consumption did not show a heterogeneous association with breast cancer across the BI-RADS categories. Several known risk factors of breast cancer had a heterogeneous effect on breast cancer development across breast density categories, especially in postmenopausal women. | en_US |
dc.description.sponsorship | This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2019R1H1A1079862) and a research grant in 2019 by the Korean Foundation for Cancer Research, Seoul, Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.subject | breast cancer | en_US |
dc.subject | Breast Imaging-Reporting and Data System | en_US |
dc.subject | breast density | en_US |
dc.subject | risk factors | en_US |
dc.subject | heterogeneous effect | en_US |
dc.title | Heterogenous Effect of Risk Factors on Breast Cancer across the Breast Density Categories in a Korean Screening Population | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 12 | - |
dc.identifier.doi | 10.3390/cancers12061391 | - |
dc.relation.page | 1391-1391 | - |
dc.relation.journal | CANCERS | - |
dc.contributor.googleauthor | Park, Boyoung | - |
dc.contributor.googleauthor | Lim, Se-Eun | - |
dc.contributor.googleauthor | Ahn, HyoJin | - |
dc.contributor.googleauthor | Yoon, Junghyun | - |
dc.contributor.googleauthor | Choi, Yun Su | - |
dc.relation.code | 2020047041 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hayejine | - |
dc.identifier.orcid | https://orcid.org/0000-0003-1902-3184 | - |
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