Regenerative Medicine of the Bile Duct: Beyond the Myth
- Title
- Regenerative Medicine of the Bile Duct: Beyond the Myth
- Author
- 김한준
- Keywords
- Cholangiocytes; Cholangiopathies; Biliary regeneration; Human derived pluripotent stem cells; Bioprinting; Stem cell therapy
- Issue Date
- 2019-07
- Publisher
- KOREAN SOC STEM CELL RESEARCH
- Citation
- INTERNATIONAL JOURNAL OF STEM CELLS, v. 12, NO 2, Page. 183-194
- Abstract
- Cholangiopathies are rare diseases of the bile duct with high mortality rates. The current treatment for cholangiopathies is liver transplantation, but there are significant obstacles including a shortage of donors and a high risk of complications. Currently, there is only one available medicine on the market targeting cholangiopathies, and the results have been inadequate in clinical therapy. To overcome these obstacles, many researchers have used human induced pluripotent stem cells (hPSC) as a source for cholangiocyte-like cell generation and have incorporated advances in bioprinting to create artificial bile ducts for implantation and transplantation. This has allowed the field to move dramatically forward in studies of biliary regenerative medicine. In this review, the authors provide an overview of cholangiocytes, the organogenesis of the bile duct, cholangiopathies, and the current treatment and advances that have been made that are opening new doors to the study of cholangiopathies.
- URI
- http://www.ijstemcell.com/journal/view.html?doi=10.15283/ijsc18055https://repository.hanyang.ac.kr/handle/20.500.11754/152054
- ISSN
- 2005-3606; 2005-5447
- DOI
- 10.15283/ijsc18055
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
- Regenerative Medicine of the Bile Duct Beyond the Myth.pdfDownload
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