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Regenerative Medicine of the Bile Duct: Beyond the Myth

Title
Regenerative Medicine of the Bile Duct: Beyond the Myth
Author
김한준
Keywords
Cholangiocytes; Cholangiopathies; Biliary regeneration; Human derived pluripotent stem cells; Bioprinting; Stem cell therapy
Issue Date
2019-07
Publisher
KOREAN SOC STEM CELL RESEARCH
Citation
INTERNATIONAL JOURNAL OF STEM CELLS, v. 12, NO 2, Page. 183-194
Abstract
Cholangiopathies are rare diseases of the bile duct with high mortality rates. The current treatment for cholangiopathies is liver transplantation, but there are significant obstacles including a shortage of donors and a high risk of complications. Currently, there is only one available medicine on the market targeting cholangiopathies, and the results have been inadequate in clinical therapy. To overcome these obstacles, many researchers have used human induced pluripotent stem cells (hPSC) as a source for cholangiocyte-like cell generation and have incorporated advances in bioprinting to create artificial bile ducts for implantation and transplantation. This has allowed the field to move dramatically forward in studies of biliary regenerative medicine. In this review, the authors provide an overview of cholangiocytes, the organogenesis of the bile duct, cholangiopathies, and the current treatment and advances that have been made that are opening new doors to the study of cholangiopathies.
URI
http://www.ijstemcell.com/journal/view.html?doi=10.15283/ijsc18055https://repository.hanyang.ac.kr/handle/20.500.11754/152054
ISSN
2005-3606; 2005-5447
DOI
10.15283/ijsc18055
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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