miR-340-5p Suppresses Aggressiveness in Glioblastoma Multiforme by Targeting Bcl-w and Sox2
- Title
- miR-340-5p Suppresses Aggressiveness in Glioblastoma Multiforme by Targeting Bcl-w and Sox2
- Author
- 정희용
- Keywords
- CANCER STEM-CELLS; DOWN-REGULATION; GROWTH-FACTORS; BREAST-CANCER; EXPRESSION; PDGF; INVASION; PROLIFERATION; PROGRESSION; TRANSITION
- Issue Date
- 2019-09
- Publisher
- CELL PRESS
- Citation
- MOLECULAR THERAPY-NUCLEIC ACIDS, v. 17, Page. 245-255
- Abstract
- Glioblastoma multiforme (GBM), a particularly aggressive type of malignant brain tumor, has a high mortality rate. Bcl-w, an oncogene, is reported to enhance cell survival, proliferation, epithelial-mesenchymal transition (EMT), migratory and invasive abilities, and stemness maintenance in a variety of cancer cell types, including GBM. In this study, we confirmed that Bcl-w-induced conditional medium (CM) enhances tumorigenic phenotypes of migration, invasiveness, and stemness maintenance. Notably, platelet-derived growth factor-A (PDGF-A) expression, among other factors of the tumor environment, was increased by CM of Bcl-w-overexpressing cells, prompting investigation of the potential correlation between Bcl-w and PDGF-A and their effects on GBM malignancy. Bcl-w and PDGF-A levels were positively regulated and increased tumorigenicity by Sox2 activation in GBM cells. miR-340-5p was further identified as a direct inhibitor of Bcl-w and Sox2. Overexpression of miR-340-5p reduced mesenchymal traits, cell migration, invasion, and stemness in GBM through attenuating Bcl-w and Sox2 expression. Our novel findings highlight the potential utility of miR-340-5p as a therapeutic agent for glioblastoma multiforme through inhibitory effects on Bcl-w-induced PDGF-A and Sox2 activation.
- URI
- https://www.sciencedirect.com/science/article/pii/S2162253119301520?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/151831
- ISSN
- 2162-2531
- DOI
- 10.1016/j.omtn.2019.05.022
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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- miR-340-5p Suppresses Aggressiveness in Glioblastoma Multiforme by Targeting Bcl-w and Sox2.pdfDownload
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