Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정희용 | - |
dc.date.accessioned | 2020-07-22T01:30:32Z | - |
dc.date.available | 2020-07-22T01:30:32Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.citation | MOLECULAR THERAPY-NUCLEIC ACIDS, v. 17, Page. 245-255 | en_US |
dc.identifier.issn | 2162-2531 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S2162253119301520?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/151831 | - |
dc.description.abstract | Glioblastoma multiforme (GBM), a particularly aggressive type of malignant brain tumor, has a high mortality rate. Bcl-w, an oncogene, is reported to enhance cell survival, proliferation, epithelial-mesenchymal transition (EMT), migratory and invasive abilities, and stemness maintenance in a variety of cancer cell types, including GBM. In this study, we confirmed that Bcl-w-induced conditional medium (CM) enhances tumorigenic phenotypes of migration, invasiveness, and stemness maintenance. Notably, platelet-derived growth factor-A (PDGF-A) expression, among other factors of the tumor environment, was increased by CM of Bcl-w-overexpressing cells, prompting investigation of the potential correlation between Bcl-w and PDGF-A and their effects on GBM malignancy. Bcl-w and PDGF-A levels were positively regulated and increased tumorigenicity by Sox2 activation in GBM cells. miR-340-5p was further identified as a direct inhibitor of Bcl-w and Sox2. Overexpression of miR-340-5p reduced mesenchymal traits, cell migration, invasion, and stemness in GBM through attenuating Bcl-w and Sox2 expression. Our novel findings highlight the potential utility of miR-340-5p as a therapeutic agent for glioblastoma multiforme through inhibitory effects on Bcl-w-induced PDGF-A and Sox2 activation. | en_US |
dc.description.sponsorship | Patient-derived GSC, X08 cells were kindly provided by Deric M. Park at the National Cancer Institute (Bethesda, MD, USA). This study was supported by a grant from the Korea Institute of Radiological and Medical Sciences (KIRAMS) and funded by the Basic Science Research Program through the National Research Foundation of Korea (NRF) and Ministry of Science and ICT (MSIT), Republic of Korea. (no. NRF-2017M2A2A7A01018542(50035-2019); 50531-2019). | en_US |
dc.language.iso | en | en_US |
dc.publisher | CELL PRESS | en_US |
dc.subject | CANCER STEM-CELLS | en_US |
dc.subject | DOWN-REGULATION | en_US |
dc.subject | GROWTH-FACTORS | en_US |
dc.subject | BREAST-CANCER | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | PDGF | en_US |
dc.subject | INVASION | en_US |
dc.subject | PROLIFERATION | en_US |
dc.subject | PROGRESSION | en_US |
dc.subject | TRANSITION | en_US |
dc.title | miR-340-5p Suppresses Aggressiveness in Glioblastoma Multiforme by Targeting Bcl-w and Sox2 | en_US |
dc.type | Article | en_US |
dc.relation.volume | 17 | - |
dc.identifier.doi | 10.1016/j.omtn.2019.05.022 | - |
dc.relation.page | 245-255 | - |
dc.relation.journal | MOLECULAR THERAPY-NUCLEIC ACIDS | - |
dc.contributor.googleauthor | Kim, Sanghwa | - |
dc.contributor.googleauthor | Choi, Jae Yeon | - |
dc.contributor.googleauthor | Seok, Hyun Jeong | - |
dc.contributor.googleauthor | Park, Myung-Jin | - |
dc.contributor.googleauthor | Chung, Hee Yong | - |
dc.contributor.googleauthor | Bae, In Hwa | - |
dc.relation.code | 2019042952 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hychung | - |
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