Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한명훈 | - |
dc.date.accessioned | 2019-12-03T02:13:36Z | - |
dc.date.available | 2019-12-03T02:13:36Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | PLOS ONE, v. 12, no. 12, Article no. e0189499 | en_US |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189499 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/116694 | - |
dc.description.abstract | Background and purposeHydrocephalus is a frequent complication following subarachnoid hemorrhage. Few studies investigated the association between laboratory parameters and shunt-dependent hydrocephalus. This study aimed to investigate the variations of laboratory parameters after subarachnoid hemorrhage. We also attempted to identify predictive laboratory parameters for shunt-dependent hydrocephalus.MethodsMultiple imputation was performed to fill the missing laboratory data using Bayesian methods in SPSS. We used univariate and multivariate Cox regression analyses to calculate hazard ratios for shunt-dependent hydrocephalus based on clinical and laboratory factors. The area under the receiver operating characteristic curve was used to determine the laboratory risk values predicting shunt-dependent hydrocephalus.ResultsWe included 181 participants with a mean age of 54.4 years. Higher sodium (hazard ratio, 1.53; 95% confidence interval, 1.13-2.07; p = 0.005), lower potassium, and higher glucose levels were associated with higher shunt-dependent hydrocephalus. The receiver operating characteristic curve analysis showed that the areas under the curve of sodium, potassium, and glucose were 0.649 (cutoff value, 142.75 mEq/L), 0.609 (cutoff value, 3.04 mmol/L), and 0.664 (cutoff value, 140.51 mg/dL), respectively.ConclusionsDespite the exploratory nature of this study, we found that higher sodium, lower potassium, and higher glucose levels were predictive values for shunt -dependent hydrocephalus from postoperative day (POD) 1 to POD 12-16 after subarachnoid hemorrhage. Strict correction of electrolyte imbalance seems necessary to reduce shunt-dependent hydrocephalus. Further large studies are warranted to confirm our findings. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (HY-201600000002777) URLs: http://www.hanyang.ac.kr/ The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PUBLIC LIBRARY SCIENCE | en_US |
dc.subject | RUPTURED INTRACRANIAL ANEURYSMS | en_US |
dc.subject | HYPERNATREMIA | en_US |
dc.subject | HYPERGLYCEMIA | en_US |
dc.subject | RISK | en_US |
dc.subject | METAANALYSIS | en_US |
dc.subject | HYPONATREMIA | en_US |
dc.subject | MORTALITY | en_US |
dc.subject | COILING | en_US |
dc.subject | BRAIN | en_US |
dc.subject | TERM | en_US |
dc.title | Early variations of laboratory parameters predicting shunt-dependent hydrocephalus after subarachnoid hemorrhage | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1371/journal.pone.0189499 | - |
dc.relation.journal | PLOS ONE | - |
dc.contributor.googleauthor | Na, Min Kyun | - |
dc.contributor.googleauthor | Won, Yu Deok | - |
dc.contributor.googleauthor | Kim, Choong Hyun | - |
dc.contributor.googleauthor | Kim, Jae Min | - |
dc.contributor.googleauthor | Cheong, Jin Hwan | - |
dc.contributor.googleauthor | Ryu, Je Il | - |
dc.contributor.googleauthor | Han, Myung-Hoon | - |
dc.relation.code | 2017006599 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | gksmh80 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.