TY - JOUR AU - 한명훈 DA - 2017/12 PY - 2017 UR - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189499 UR - https://repository.hanyang.ac.kr/handle/20.500.11754/116694 AB - Background and purposeHydrocephalus is a frequent complication following subarachnoid hemorrhage. Few studies investigated the association between laboratory parameters and shunt-dependent hydrocephalus. This study aimed to investigate the variations of laboratory parameters after subarachnoid hemorrhage. We also attempted to identify predictive laboratory parameters for shunt-dependent hydrocephalus.MethodsMultiple imputation was performed to fill the missing laboratory data using Bayesian methods in SPSS. We used univariate and multivariate Cox regression analyses to calculate hazard ratios for shunt-dependent hydrocephalus based on clinical and laboratory factors. The area under the receiver operating characteristic curve was used to determine the laboratory risk values predicting shunt-dependent hydrocephalus.ResultsWe included 181 participants with a mean age of 54.4 years. Higher sodium (hazard ratio, 1.53; 95% confidence interval, 1.13-2.07; p = 0.005), lower potassium, and higher glucose levels were associated with higher shunt-dependent hydrocephalus. The receiver operating characteristic curve analysis showed that the areas under the curve of sodium, potassium, and glucose were 0.649 (cutoff value, 142.75 mEq/L), 0.609 (cutoff value, 3.04 mmol/L), and 0.664 (cutoff value, 140.51 mg/dL), respectively.ConclusionsDespite the exploratory nature of this study, we found that higher sodium, lower potassium, and higher glucose levels were predictive values for shunt -dependent hydrocephalus from postoperative day (POD) 1 to POD 12-16 after subarachnoid hemorrhage. Strict correction of electrolyte imbalance seems necessary to reduce shunt-dependent hydrocephalus. Further large studies are warranted to confirm our findings. PB - PUBLIC LIBRARY SCIENCE KW - RUPTURED INTRACRANIAL ANEURYSMS KW - HYPERNATREMIA KW - HYPERGLYCEMIA KW - RISK KW - METAANALYSIS KW - HYPONATREMIA KW - MORTALITY KW - COILING KW - BRAIN KW - TERM TI - Early variations of laboratory parameters predicting shunt-dependent hydrocephalus after subarachnoid hemorrhage DO - 10.1371/journal.pone.0189499 T2 - PLOS ONE ER -