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Retarded dissolution of ibuprofen in gelatin microcapsule by cross-linking with glutaradehyde

Title
Retarded dissolution of ibuprofen in gelatin microcapsule by cross-linking with glutaradehyde
Author
최한곤
Keywords
ibuprofen; cross-linked gelatin microcapsule; glutaraldehyde; dissolution
Issue Date
2006-06
Publisher
PHARMACEUTICAL SOCIETY KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v. 29, No. 6, Page. 520-524
Abstract
Ibuprofen-loaded gelatin microcapsule, a solid form of microcapsules simultaneously containing ethanol and ibuprofen in water-soluble gelatin shell was previously reported to improve the dissolution of drug. In this study, to retard the initial high dissolution of ibuprofen from gelatin microcapsule, the ibuprofen-loaded cross-linked gelatin microcapsule was prepared by treating an ibuprofen-loaded gelatin microcapsule with glutaraldehyde and its dissolution was evaluated compared to ibuprofen powder and gelatin microcapsule. The ibuprofen-loaded crosslinked microcapsule treated with glutaraldehyde for 10 and 60 sec gave significantly higher dissolution rates than did ibuprofen powder. Furthermore, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 10 sec was similar to that from gelatin microcapsule. However, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 60 sec decreased significantly compared to gelatin microcapsule, suggesting that the treatment of gelatin microcapsule with glutaraldehyde for 60 sec could cross-link the gelatin microcapsule. Furthermore, the cross-linking of gelatin microcapsule markedly retarded the release rate of ibuprofen in pH 1.2 simulated gastric fluid compared to gelatin microcapsule. However, the cross-linking of gelatin microcapsule with glutaraldehyde hardly changed the size of gelatin microcapsules, ethanol and ibuprofen contents encapsulated in gelatin microcapsule. Thus, the ibuprofen-loaded cross-linked gelatin microcapsule could retard the initial high dissolution of poorly water-soluble ibuprofen.
URI
https://link.springer.com/article/10.1007/BF02969427http://repository.hanyang.ac.kr/handle/20.500.11754/108168
ISSN
0253-6269; 1976-3786
DOI
10.1007/BF02969427
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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