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dc.contributor.author최한곤-
dc.date.accessioned2019-08-02T07:11:16Z-
dc.date.available2019-08-02T07:11:16Z-
dc.date.issued2006-06-
dc.identifier.citationARCHIVES OF PHARMACAL RESEARCH, v. 29, No. 6, Page. 520-524en_US
dc.identifier.issn0253-6269-
dc.identifier.issn1976-3786-
dc.identifier.urihttps://link.springer.com/article/10.1007/BF02969427-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/108168-
dc.description.abstractIbuprofen-loaded gelatin microcapsule, a solid form of microcapsules simultaneously containing ethanol and ibuprofen in water-soluble gelatin shell was previously reported to improve the dissolution of drug. In this study, to retard the initial high dissolution of ibuprofen from gelatin microcapsule, the ibuprofen-loaded cross-linked gelatin microcapsule was prepared by treating an ibuprofen-loaded gelatin microcapsule with glutaraldehyde and its dissolution was evaluated compared to ibuprofen powder and gelatin microcapsule. The ibuprofen-loaded crosslinked microcapsule treated with glutaraldehyde for 10 and 60 sec gave significantly higher dissolution rates than did ibuprofen powder. Furthermore, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 10 sec was similar to that from gelatin microcapsule. However, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 60 sec decreased significantly compared to gelatin microcapsule, suggesting that the treatment of gelatin microcapsule with glutaraldehyde for 60 sec could cross-link the gelatin microcapsule. Furthermore, the cross-linking of gelatin microcapsule markedly retarded the release rate of ibuprofen in pH 1.2 simulated gastric fluid compared to gelatin microcapsule. However, the cross-linking of gelatin microcapsule with glutaraldehyde hardly changed the size of gelatin microcapsules, ethanol and ibuprofen contents encapsulated in gelatin microcapsule. Thus, the ibuprofen-loaded cross-linked gelatin microcapsule could retard the initial high dissolution of poorly water-soluble ibuprofen.en_US
dc.language.isoen_USen_US
dc.publisherPHARMACEUTICAL SOCIETY KOREAen_US
dc.subjectibuprofenen_US
dc.subjectcross-linked gelatin microcapsuleen_US
dc.subjectglutaraldehydeen_US
dc.subjectdissolutionen_US
dc.titleRetarded dissolution of ibuprofen in gelatin microcapsule by cross-linking with glutaradehydeen_US
dc.typeArticleen_US
dc.relation.volume29-
dc.identifier.doi10.1007/BF02969427-
dc.relation.page520-524-
dc.relation.journalARCHIVES OF PHARMACAL RESEARCH-
dc.contributor.googleauthorYong, CS-
dc.contributor.googleauthorLi, DX-
dc.contributor.googleauthorOh, DH-
dc.contributor.googleauthorKim, JA-
dc.contributor.googleauthorYoo, BK-
dc.contributor.googleauthorWoo, JS-
dc.contributor.googleauthorRhee, JD-
dc.contributor.googleauthorChoi, HG-
dc.relation.code2011200969-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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