Retarded dissolution of ibuprofen in gelatin microcapsule by cross-linking with glutaradehyde
- Title
- Retarded dissolution of ibuprofen in gelatin microcapsule by cross-linking with glutaradehyde
- Author
- 최한곤
- Keywords
- ibuprofen; cross-linked gelatin microcapsule; glutaraldehyde; dissolution
- Issue Date
- 2006-06
- Publisher
- PHARMACEUTICAL SOCIETY KOREA
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v. 29, No. 6, Page. 520-524
- Abstract
- Ibuprofen-loaded gelatin microcapsule, a solid form of microcapsules simultaneously containing ethanol and ibuprofen in water-soluble gelatin shell was previously reported to improve the dissolution of drug. In this study, to retard the initial high dissolution of ibuprofen from gelatin microcapsule, the ibuprofen-loaded cross-linked gelatin microcapsule was prepared by treating an ibuprofen-loaded gelatin microcapsule with glutaraldehyde and its dissolution was evaluated compared to ibuprofen powder and gelatin microcapsule. The ibuprofen-loaded crosslinked microcapsule treated with glutaraldehyde for 10 and 60 sec gave significantly higher dissolution rates than did ibuprofen powder. Furthermore, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 10 sec was similar to that from gelatin microcapsule. However, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 60 sec decreased significantly compared to gelatin microcapsule, suggesting that the treatment of gelatin microcapsule with glutaraldehyde for 60 sec could cross-link the gelatin microcapsule. Furthermore, the cross-linking of gelatin microcapsule markedly retarded the release rate of ibuprofen in pH 1.2 simulated gastric fluid compared to gelatin microcapsule. However, the cross-linking of gelatin microcapsule with glutaraldehyde hardly changed the size of gelatin microcapsules, ethanol and ibuprofen contents encapsulated in gelatin microcapsule. Thus, the ibuprofen-loaded cross-linked gelatin microcapsule could retard the initial high dissolution of poorly water-soluble ibuprofen.
- URI
- https://link.springer.com/article/10.1007/BF02969427https://repository.hanyang.ac.kr/handle/20.500.11754/108168
- ISSN
- 0253-6269; 1976-3786
- DOI
- 10.1007/BF02969427
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML