Anti-aging potential of fish collagen hydrolysates subjected to simulated gastrointestinal digestion and Caco-2 cell permeation
- Title
- Anti-aging potential of fish collagen hydrolysates subjected to simulated gastrointestinal digestion and Caco-2 cell permeation
- Author
- 이현규
- Keywords
- Anti-aging peptide; Cellular permeability; Collagen synthesis Fish collagen hydrolysate; Matrix metalloproteinase-1 inhibition
- Issue Date
- 2019-03
- Publisher
- 한국응용생명화학회
- Citation
- Journal of Applied Biological Chemistry, v. 62, NO 1, Page. 101-107
- Abstract
- The objectives of this study were to evaluate the antiaging effects and investigate the effect of simulated gastrointestinal (GI) digestion on the anti-aging properties and intestinal permeation of the potential fish collagen hydrolysates (FCH). Therefore, procollagen synthesis, matrix metalloproteinase-1 (MMP-1) production, and Caco-2 cell permeability were analyzed before and after in vitro digestion for FCHs, low-molecular weight fractions (˂1 kDa), and high molecular weight fractions (˃1 kDa).
After being subjected to GI digestion, the level of MMP-1 inhibition was maintained, although the procollagen production was significantly (˃20%) lower with all samples. Also, the digested FCHs and their ˂1 kDa fraction yielded 9.1 and 13.8% increased peptide transport, respectively, compared to undigested samples. Based on the effective intestinal permeation and high digestive enzyme stability, the ˂1 kDa fraction of FCHs is a potential bioactive material suitable for anti-aging applications in the food and cosmetics industries.
- URI
- http://www.jabc.or.kr/journal/view.html?doi=10.3839/jabc.2019.015https://repository.hanyang.ac.kr/handle/20.500.11754/104592
- ISSN
- 1976-0442; 2234-7941
- DOI
- 10.3839/jabc.2019.015
- Appears in Collections:
- COLLEGE OF HUMAN ECOLOGY[S](생활과학대학) > FOOD & NUTRITION(식품영양학과) > Articles
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