Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이현규 | - |
dc.date.accessioned | 2019-05-20T00:58:08Z | - |
dc.date.available | 2019-05-20T00:58:08Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | Journal of Applied Biological Chemistry, v. 62, NO 1, Page. 101-107 | en_US |
dc.identifier.issn | 1976-0442 | - |
dc.identifier.issn | 2234-7941 | - |
dc.identifier.uri | http://www.jabc.or.kr/journal/view.html?doi=10.3839/jabc.2019.015 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/104592 | - |
dc.description.abstract | The objectives of this study were to evaluate the antiaging effects and investigate the effect of simulated gastrointestinal (GI) digestion on the anti-aging properties and intestinal permeation of the potential fish collagen hydrolysates (FCH). Therefore, procollagen synthesis, matrix metalloproteinase-1 (MMP-1) production, and Caco-2 cell permeability were analyzed before and after in vitro digestion for FCHs, low-molecular weight fractions (˂1 kDa), and high molecular weight fractions (˃1 kDa). After being subjected to GI digestion, the level of MMP-1 inhibition was maintained, although the procollagen production was significantly (˃20%) lower with all samples. Also, the digested FCHs and their ˂1 kDa fraction yielded 9.1 and 13.8% increased peptide transport, respectively, compared to undigested samples. Based on the effective intestinal permeation and high digestive enzyme stability, the ˂1 kDa fraction of FCHs is a potential bioactive material suitable for anti-aging applications in the food and cosmetics industries. | en_US |
dc.description.sponsorship | This work was supported by the Far East University Research Grant (FEU2018S03). | en_US |
dc.language.iso | en | en_US |
dc.publisher | 한국응용생명화학회 | en_US |
dc.subject | Anti-aging peptide | en_US |
dc.subject | Cellular permeability | en_US |
dc.subject | Collagen synthesis Fish collagen hydrolysate | en_US |
dc.subject | Matrix metalloproteinase-1 inhibition | en_US |
dc.title | Anti-aging potential of fish collagen hydrolysates subjected to simulated gastrointestinal digestion and Caco-2 cell permeation | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 62 | - |
dc.identifier.doi | 10.3839/jabc.2019.015 | - |
dc.relation.page | 101-107 | - |
dc.relation.journal | Applied Biological Chemistry | - |
dc.contributor.googleauthor | Je, Hyun Jeong | - |
dc.contributor.googleauthor | Han, Yoo Kyung | - |
dc.contributor.googleauthor | Lee, Hyeon Gyu | - |
dc.contributor.googleauthor | Bae, In Young | - |
dc.relation.code | 2019035496 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | hyeonlee | - |
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