Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류종석 | - |
dc.date.accessioned | 2018-12-06T07:15:55Z | - |
dc.date.available | 2018-12-06T07:15:55Z | - |
dc.date.issued | 2008-11 | - |
dc.identifier.citation | International Journal of Medical Sciences, v. 5, No. 6, Page. 347-353 | en_US |
dc.identifier.issn | 1449-1907 | - |
dc.identifier.uri | http://www.medsci.org/v05p0347.htm | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/80766 | - |
dc.description.abstract | Prion diseases are caused by proteinaceous pathogens termed prions. Although the details of the mechanism of prion propagation are not fully understood, conformational conversion of cellular prion protein (PrP C) to misfolded, disease-associated scrapie prion protein (PrP Sc) is considered the essential biochemical event for prion replication. Currently, studying prion replication in vitro is difficult due to the lack of a system which fully recapitulates the in vivo phenomenon. Over the last 15 years, a number of in vitro systems supporting PrPC conversion, PrPSc amplification, or amyloid fibril formation have been established. In this review, we describe the evolving methodology of in vitro prion propagation assays and discuss their ability in reflecting prion propagation in vivo. © Ivyspring International Publisher. All rights reserved. | en_US |
dc.description.sponsorship | Authors thank William Titlow for his assistance in preparation of this manuscript. Authors' group was supported in part by funds from the University of Kentucky Sanders Brown Center on Aging. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Ivyspring International Publisher | en_US |
dc.subject | Cellular prion protein | en_US |
dc.subject | Disease-associated scrapie prion protein | en_US |
dc.subject | In vitro conversion | en_US |
dc.subject | In vitro prion amplification | en_US |
dc.subject | Prion | en_US |
dc.subject | Prion disease | en_US |
dc.subject | Prion infectivity | en_US |
dc.title | Prion propagation in vitro: Are we there yet? | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 5 | - |
dc.identifier.doi | 10.7150/ijms.5.347 | - |
dc.relation.page | 347-353 | - |
dc.relation.journal | International Journal of Medical Sciences | - |
dc.contributor.googleauthor | Ryou, Chongsuk | - |
dc.contributor.googleauthor | Mays, Charles E. | - |
dc.relation.code | 2012247105 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | cryou2 | - |
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