Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2018-10-25T00:31:11Z | - |
dc.date.available | 2018-10-25T00:31:11Z | - |
dc.date.issued | 2008-01 | - |
dc.identifier.citation | FOOD SCIENCE AND BIOTECHNOLOGY, v. 17, No. 1, Page. 203-207 | en_US |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | http://agris.fao.org/agris-search/search.do?recordID=KR2008003809 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/76687 | - |
dc.description.abstract | The present study aimed at assessing the protective effect of water extract from fruit body of the Grifola frondosa (GFW) on carbon tetrachloride (CCl4)-induced hepatotoxicity. Rats orally administered with GFW 0.5, 1.0, 2.0 g/kg for 14 days were treated with CCl4 to induce hepatotoxicity. Pretreatment with GFW remarkably prevented the elevation of serum AST, ALT, ALP, LDH, gamma-GTP, and liver lipid peroxides in CCl4-treated rat and GFW administration in liver injured rats by CC showed significant (p < 0.05) protection of liver as evidenced from normal serum enzymes and malondialdehyde (MDA) levels. In the ultrastructural changes, administration Of CCl4-induced damage of hepatocytes with vacuolation, a highly damaged endoplasmic reticulum, and degenerating nuclei. However, pre-administration with GFW preserved normal ultrastructure of hepatocytes. These results suggest that GFW had an effect to inhibit CCl4-induced liver injury in rat, and that it could be used as an effective hepatoprotective agent against chemical-induced liver damage. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN SOC FOOD SCIENCE TECHNOLOGY | en_US |
dc.subject | Grifola frondosa | en_US |
dc.subject | carbon tetrachloride (CCl4) | en_US |
dc.subject | hepatoprotection | en_US |
dc.subject | ultrastructural change | en_US |
dc.subject | aspartate aminotransferase (AST)/alanine aminotransferase (ALT) | en_US |
dc.title | Hepatoprotective effect of Grifola frondosa water extract on carbon tetrachloride-induced liver injury in rats | en_US |
dc.type | Article | en_US |
dc.relation.volume | 17 | - |
dc.relation.page | 203-207 | - |
dc.relation.journal | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.contributor.googleauthor | Lee, Jong-Sulk | - |
dc.contributor.googleauthor | Kim, Han-Sup | - |
dc.contributor.googleauthor | Lee, Yoon-Joo | - |
dc.contributor.googleauthor | Yong, Cheol-Soon | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.contributor.googleauthor | Han, Gi-Dong | - |
dc.contributor.googleauthor | Vim, Jung-Ae | - |
dc.contributor.googleauthor | Lee, Jae-Sung | - |
dc.relation.code | 2008212142 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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