Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma
- Title
- Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma
- Author
- 오재원
- Issue Date
- 2011-12
- Publisher
- AMERICAN COLLEGE OF ALLERGY, ASTHMA, & IMMUNOLOGY
- Citation
- Annals of allergy, asthma, and immunology, 2011, 107(1), P.14-21
- Abstract
- Background
Exercise-induced bronchoconstriction (EIB), a form of bronchial hyperresponsiveness (BHR), is common in children with asthma or obesity. Epidemiological studies have shown that asthma and obesity are increasing in parallel, but obesity- and adipokine-related effects on inflammation and BHR have not yet been demonstrated in the human airway.
Objective
To address the relationship between leptin and adiponectin and EIB in children with asthma.
Methods
Eighty-five prepubertal children between the ages of 6 and 10 years were included in our study. They comprised obese with asthma (n = 19), normal weight with asthma (n = 23), obese without asthma (n = 23), and healthy (n = 20). We measured seum leptin and adiponectin levels. We also performed pulmonary function tests: baseline, postbronchodilator inhalation, methacholine inhalation, and exercise. The area under the forced expiratory volume in 1 second (FEV1)–time curve quantified the severity of EIB over a 20-minute period after exercise (AUC20).
Results
The obese children had significantly elevated levels of leptin and reduced levels of adiponectin. The maximum decreases in %FEV1 and AUC20 after exercise were positively correlated with leptin levels and negatively with serum adiponectin levels in children with asthma. The odds for having EIB were incrementally and significantly higher for children with higher levels of serum leptin.
Conclusions
Levels of the adipocyte-derived hormones leptin and adiponectin are significantly correlated with BHR induced by exercise challenge in children with asthma. Further studies are needed to elucidate whether the changes in leptin and adiponectin levels bear a causal relationship to the EIB/BHR.
- URI
- https://www.sciencedirect.com/science/article/pii/S108112061100233Xhttps://repository.hanyang.ac.kr/handle/20.500.11754/72974
- ISSN
- 1081-1206
- DOI
- 10.1016/j.anai.2011.03.013
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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