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dc.contributor.author최한곤-
dc.date.accessioned2018-06-27T01:13:53Z-
dc.date.available2018-06-27T01:13:53Z-
dc.date.issued2017-07-
dc.identifier.citationCOLLOIDS AND SURFACES B-BIOINTERFACES, v. 158, Page. 157-166en_US
dc.identifier.issn0927-7765-
dc.identifier.issn1873-4367-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0927776517303983-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/72224-
dc.description.abstractAlbumin nanoparticles are well-known as effective drug carriers used to deliver hydrophobic chemotherapeutic agents. Albumin nanoparticles encapsulating curcumin and doxorubicin were fabricated using slightly modified nanoparticle albumin-bound (nab (TM)) technology, and the synergistic effects of these two drugs were examined. Albumin nanoparticles encapsulating curcumin, doxorubicin, and both curcumin and doxorubicin were prepared using a high pressure homogenizer. The sizes of albumin nanoparticles were similar to 130 nm, which was considered to be suitable for the EPR (enhanced permeability and retention) effect. Albumin nanoparticles gradually released drugs over a period of 24 h without burst effect. To confirm the synergistic effect of two drugs, in vitro cytotoxicity assay was performed using B16F10 melanoma cells. The cytotoxic effect on B16F10 melanoma cells was highest when co-treated with both curcumin and doxorubicin compared to single treatment of either curcumin and doxorubicin. The combined index calculated by medium-effect equation was 0.6069, indicating a synergistic effect. Results of confocal laser scanning microscopy and fluorescence-activated cell sorting corresponded to results from an in vitro cytotoxicity assay, indicating synergistic cytotoxicity induced by both drugs. A C57BL/6 mouse model induced by B16F10 lung metastasis was used to study in vivo therapeutic effects. When curcumin and doxorubicin were simultaneously treated, the metastatic melanoma mass in the lungs macroscopically decreased compared to curcumin or doxorubicin alone. Albumin nanoparticles encapsulating two anticancer drugs were shown to have an effective therapeutic result and would be an excellent way to treat resistant lung cancers. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis research was supported by a grant (16173MFDS542) from the Ministry of Food and Drug Safety in 2017.en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectAlbuminen_US
dc.subjectNanoparticlesen_US
dc.subjectSynergistic efficacyen_US
dc.subjectMetastatic lung cancersen_US
dc.subjectTargetingen_US
dc.titleAlbumin nanoparticles with synergistic antitumor efficacy against metastatic lung cancersen_US
dc.typeArticleen_US
dc.relation.volume158-
dc.identifier.doi10.1016/j.colsurfb.2017.06.039-
dc.relation.page157-166-
dc.relation.journalCOLLOIDS AND SURFACES B-BIOINTERFACES-
dc.contributor.googleauthorKim, Bomi-
dc.contributor.googleauthorSeo, Bohyung-
dc.contributor.googleauthorPark, Sanghyun-
dc.contributor.googleauthorLee, Changkyu-
dc.contributor.googleauthorKim, Jong Oh-
dc.contributor.googleauthorOh, Kyung Taek-
dc.contributor.googleauthorLee, Eun Seong-
dc.contributor.googleauthorChoi, Han-Gon-
dc.contributor.googleauthorYoun, Yu Seok-
dc.relation.code2017001472-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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