Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이지수 | - |
dc.date.accessioned | 2018-05-25T06:20:34Z | - |
dc.date.available | 2018-05-25T06:20:34Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v. 64, NO 23, Page. 4765-4771 | en_US |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.issn | 1520-5118 | - |
dc.identifier.uri | https://pubs.acs.org/doi/10.1021/acs.jafc.6b00911 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/71519 | - |
dc.description.abstract | The potential of nanoencapsulation using bioactive coating materials for improving antithrombotic activities of red ginseng extract (RG) was examined. RG-loaded chitosan (CS) nanoparticles were prepared using antithrombotic materials, polyglutamic acid (PGA) or fucoidan (Fu). Both CS-PGA (P-NPs, 360 +/- 67 nm) and CS-Fu nanoparticles (F-NPs, 440 +/- 44 nm) showed sustained ginsenoside release in an acidic environment and improved ginsenoside solubility by approximately 122.8%. Both in vitro rabbit and ex vivo rat platelet aggregation of RG (22.3 and 41.5%) were significantly (p ˂ 0.05) decreased within P-NPs (14.4 and 30.0%) and F-NPs (12.3 and 30.3%), respectively. Although RG exhibited no effect on in vivo carrageenan-induced mouse tail thrombosis, P-NPs and F-NPs demonstrated significant effects, likely the anticoagulation activity of PGA and Fu. Moreover, in the in vivo rat arteriovenous shunt model, P-NPs (156 +/- 6.8 mg) and F-NPs (160 +/- 3.2 mg) groups showed significantly lower thrombus formation than that of RG (190 +/- 5.5 mg). Therefore, nanoencapsulation using CS, PGA, and Fa is a potential for improving the antithrombotic activity of RG. | en_US |
dc.description.sponsorship | This work was supported by the Technological Innovation R&D Program (S2042340) funded by the Small and Medium Business Administration (SMBA, Korea). | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER CHEMICAL SOC | en_US |
dc.subject | red ginseng extracts | en_US |
dc.subject | chitosan nanoparticles | en_US |
dc.subject | ionic gelation | en_US |
dc.subject | platelet aggregation | en_US |
dc.subject | antithrombotic activity | en_US |
dc.title | Nanoencapsulation of Red Ginseng Extracts Using Chitosan with Polyglutamic Acid or Fucoidan for Improving Antithrombotic Activities | en_US |
dc.type | Article | en_US |
dc.relation.no | 23 | - |
dc.relation.volume | 64 | - |
dc.identifier.doi | 10.1021/acs.jafc.6b00911 | - |
dc.relation.page | 4765-4771 | - |
dc.relation.journal | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.contributor.googleauthor | Kim, Eun Suh | - |
dc.contributor.googleauthor | Lee, Ji-Soo | - |
dc.contributor.googleauthor | Lee, Hyeon Gyu | - |
dc.relation.code | 2016001922 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | KOREAN LIVING SCIENCE RESEARCH INSTITUTE | - |
dc.identifier.pid | iamjisoo | - |
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