Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배옥남 | - |
dc.date.accessioned | 2018-05-11T07:18:11Z | - |
dc.date.available | 2018-05-11T07:18:11Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 108, Page. 187-195 | en_US |
dc.identifier.issn | 0939-6411 | - |
dc.identifier.issn | 1873-3441 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0939641116305525 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/71332 | - |
dc.description.abstract | The aim of this study was to enhance the anti-inflammatory effects of carbon monoxide (CO) via sustained release of CO from carbon monoxide-releasing molecule-2-loaded lipid nanoparticles (CORM-2-NPs). CORM-2-NPs were prepared by hot high pressure homogenization method using trilaurin as a solid lipid core and Tween 20/Span 20/Myrj S40 as surfactant mixture. The physicochemical properties of CORM-2-NPs were characterized and CO release from CORM-2-NPs was assessed by myoglobin assay. In vitro anti-inflammatory effects were evaluated by nitric oxide assay in lipopolysaccharide-stimulated RAW 264.7 macrophages. In vivo anti-inflammatory activity was investigated by measuring paw volumes and histological examination in carrageenan-induced rat paw edema. Spherical CORM-2-NPs were around 100 nm with narrow particle size distribution. The sustained CO release from CORM-2-NPs was observed and the half-life of CO release increased up to 10 times compared with CORM-2 solution. CORM-2-NPs showed enhanced in vitro anti-inflammatory effects by inhibition of nitric oxide production. Edema volume in rat paw was significantly reduced after treatment with CORM-2-NPs. Taken together, CORM-2-NPs have a great potential for CO therapeutics against inflammation via sustained release of CO. (C) 2016 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (HY-2011-N). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Anti-inflammatory effect | en_US |
dc.subject | Carbon monoxide | en_US |
dc.subject | CORM-2 | en_US |
dc.subject | Lipid nanoparticles | en_US |
dc.subject | Sustained release | en_US |
dc.subject | CARRIERS | en_US |
dc.subject | SOLID LIPID NANOPARTICLES | en_US |
dc.subject | ORAL-DRUG DELIVERY | en_US |
dc.subject | MOLECULES CO-RMS | en_US |
dc.subject | HEME OXYGENASE | en_US |
dc.subject | RELEASE | en_US |
dc.subject | SYSTEMS | en_US |
dc.subject | SLN | en_US |
dc.subject | NANOCARRIERS | en_US |
dc.subject | MACROPHAGES | en_US |
dc.title | Enhanced acute anti-inflammatory effects of CORM-2-loaded nanoparticles via sustained carbon monoxide delivery | en_US |
dc.type | Article | en_US |
dc.relation.volume | 108 | - |
dc.identifier.doi | 0.1016/j.ejpb.2016.09.008 | - |
dc.relation.page | 187-195 | - |
dc.relation.journal | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | - |
dc.contributor.googleauthor | Qureshi, OS | - |
dc.contributor.googleauthor | Zeb, A | - |
dc.contributor.googleauthor | Akram, M | - |
dc.contributor.googleauthor | Kim, MS | - |
dc.contributor.googleauthor | Kang, JH | - |
dc.contributor.googleauthor | Kim, HS | - |
dc.contributor.googleauthor | Majid, A | - |
dc.contributor.googleauthor | Han, I | - |
dc.contributor.googleauthor | Chang, SY | - |
dc.contributor.googleauthor | Bae, ON | - |
dc.contributor.googleauthor | Kim, JK | - |
dc.relation.code | 2016000826 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | onbae | - |
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