Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2018-04-26T07:52:45Z | - |
dc.date.available | 2018-04-26T07:52:45Z | - |
dc.date.issued | 2013-11 | - |
dc.identifier.citation | NEUROBIOLOGY OF AGING, 권: 34, 호: 11, 페이지: 2482-2487 | en_US |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0197458013002078 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/70842 | - |
dc.description.abstract | The relationship between the apolipoprotein E epsilon 4 allele (APOE4) and factors associated with vascular cognitive impairment (VCI) is unclear. We aimed to examine the effects of APOE4 on brain amyloid beta using Pittsburg compound B (PiB) and subcortical cerebrovascular disease, as assessed by lacunes and white matter hyperintensities (WMH) in subcortical VCI (SVCI) patients. We recruited 230 subjects with normal cognition, 111 subjects with cognitive impairment due to clinically defined Alzheimer's disease (ADCI), and 134 subjects with clinically defined SVCI. A PiB retention ratio greater than 1.5 was considered to be PiB positive. Logistic regression analysis was performed to investigate whether APOE4 increased the risk for each cognitive impairment group. Multiple linear regression analysis was performed to investigate whether APOE4 was associated with brain amyloid beta, lacunes, and WMH. APOE4 did not increase the risk of PiB(-) SVCI (odds ratio [OR], 1.50; 95% confidence interval [CI], 0.79-2.84), whereas APOE4 increased the risk of PiB(+) SVCI (OR, 4.52; 95% CI, 1.70-11.97) and PiB(+) ADCI (odds ratio, 4.84; 95% CI, 2.54-7.91). In SVCI patients, APOE4 was positively associated with PiB retention ratio, whereas APOE4 was not associated with the number of lacunes or with WMH volume. Our results suggest that amyloid beta burden can occur in patients with and without subcortical cerebrovascular disease, and that it is associated with APOE4. However APOE4 might be independent of subcortical cerebrovascular disease. (C) 2013 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This study was supported by grants from the Korean Healthcare Technology R&D Project, the Ministry for Health, Welfare & Family Affairs, the Republic of Korea (nos. A102065 and A070001), by the Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; 2011-0028333), by Samsung Medical Center Clinical Research Development Program grants (CRL-108011 and CRS 110-14-1), and by the Converging Research Center Program through the Ministry of Education, Science and Technology (2010K001054). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA | en_US |
dc.subject | Subcortical vascular cognitive impairment | en_US |
dc.subject | APOE | en_US |
dc.subject | White matter hyperintensity | en_US |
dc.subject | Lacune | en_US |
dc.subject | Amyloid beta burden | en_US |
dc.title | Effects of APOE epsilon 4 on brain amyloid, lacunar infarcts, and white matter lesions: a study among patients with subcortical vascular cognitive impairment | en_US |
dc.type | Article | en_US |
dc.relation.no | 11 | - |
dc.relation.volume | 34 | - |
dc.identifier.doi | 10.1016/j.neurobiolaging.2013.05.009 | - |
dc.relation.page | 2482-2487 | - |
dc.relation.journal | NEUROBIOLOGY OF AGING | - |
dc.contributor.googleauthor | Kim, Hee Jin | - |
dc.contributor.googleauthor | Ye, Byoung Seok | - |
dc.contributor.googleauthor | Yoon, Cindy W. | - |
dc.contributor.googleauthor | Cho, Hanna | - |
dc.contributor.googleauthor | Noh, Young | - |
dc.contributor.googleauthor | Kim, Geon Ha | - |
dc.contributor.googleauthor | Choi, Yae Seul | - |
dc.contributor.googleauthor | Kim, Jung-Hyun | - |
dc.contributor.googleauthor | Jeon, Seun | - |
dc.contributor.googleauthor | Lee, Jong Min | - |
dc.relation.code | 2013011442 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
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